The essential role of chemokines in the selective regulation of lymphocyte homing

María Rosa Bono; Raúl Elgueta; Daniela Sauma; Karina Pino; Fabiola Osorio; Paula Michea; Alberto Fierro; Mario Rosemblatt

doi:10.1016/j.cytogfr.2007.01.004

The essential role of chemokines in the selective regulation of lymphocyte homing

María Rosa Bono, Raúl Elgueta, Daniela Sauma, Karina Pino, Fabiola Osorio, Paula Michea, Alberto Fierro, Mario Rosemblatt^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of naïve, effector, memory and regulatory T-cells is a multiple step process regulated by a specific arrangement of cytokines, chemokines and adhesion receptors that guide these cells to specific locations. Recent research has outlined two major pathways of lymphocyte trafficking under homeostatic and inflammatory conditions, one concerning tropism to cutaneous tissue and a second one related to mucosal-associated sites. In this article we will outline our present understanding of the role of cytokines and chemokines as regulators of lymphocyte migration through tissues.

Original language	English
Pages (from-to)	33-43
Number of pages	11
Journal	Cytokine and Growth Factor Reviews
Volume	18
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cytogfr.2007.01.004
State	Published - 2007
Externally published	Yes

Bibliographical note

Funding Information:
We would like to thank Dr. Rodrigo Mora (Harvard Medical School) for valuable observations and suggestions. This article was supported in part by Conicyt grants to MRB (1060834), AF (1050023) and MR (1060253) and UNAB to MR.

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cytogfr.2007.01.004

Cite this

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abstract = "Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of na{\"i}ve, effector, memory and regulatory T-cells is a multiple step process regulated by a specific arrangement of cytokines, chemokines and adhesion receptors that guide these cells to specific locations. Recent research has outlined two major pathways of lymphocyte trafficking under homeostatic and inflammatory conditions, one concerning tropism to cutaneous tissue and a second one related to mucosal-associated sites. In this article we will outline our present understanding of the role of cytokines and chemokines as regulators of lymphocyte migration through tissues.",

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note = "Funding Information: We would like to thank Dr. Rodrigo Mora (Harvard Medical School) for valuable observations and suggestions. This article was supported in part by Conicyt grants to MRB (1060834), AF (1050023) and MR (1060253) and UNAB to MR. ",

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AU - Elgueta, Raúl

AU - Sauma, Daniela

AU - Pino, Karina

AU - Osorio, Fabiola

AU - Michea, Paula

AU - Fierro, Alberto

AU - Rosemblatt, Mario

N1 - Funding Information: We would like to thank Dr. Rodrigo Mora (Harvard Medical School) for valuable observations and suggestions. This article was supported in part by Conicyt grants to MRB (1060834), AF (1050023) and MR (1060253) and UNAB to MR.

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The essential role of chemokines in the selective regulation of lymphocyte homing

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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