Synthesis and characterizations of macroporous poly(acrylamide-2- acrylamido-2-methyl-1-propanesulfonic acid) hydrogels for in vitro drug release of ranitidine hydrochloride

K. Varaprasad; N. Narayana Reddy; S. Ravindra; K. Vimala; K. Mohana Raju

doi:10.1080/00914037.2010.531816

Synthesis and characterizations of macroporous poly(acrylamide-2- acrylamido-2-methyl-1-propanesulfonic acid) hydrogels for in vitro drug release of ranitidine hydrochloride

K. Varaprasad, N. Narayana Reddy, S. Ravindra, K. Vimala, K. Mohana Raju

Sri Krishnadevaraya University India

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Macroporous hydrogels were prepared with acrylamide (AM) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) as well as with anhydrous dextrose (AD) as porogen by crosslinking with N,N1-methylenebisacrylamide (MBA). The chemical structure of hydrogels is characterized by Fourier transform infrared (FTIR) spectroscopy. Morphological studies done by scanning electron microscopy (SEM) showed the macroporous nature of the hydrogels. Swelling studies of hydrogels were done in distilled water, in aqueous NaCl solution and in different pH solutions. In addition, drug release studies of selected macroporous hydrogels (DAMPS1, DAMPS4, DAMPSM1 and DAMPSM3) are also investigated.

Original language	English
Pages (from-to)	490-503
Number of pages	14
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	60
Issue number	7
DOIs	https://doi.org/10.1080/00914037.2010.531816
State	Published - 2011
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
General Chemical Engineering
Polymers and Plastics

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Varaprasad, K., Reddy, N. N., Ravindra, S., Vimala, K., & Raju, K. M. (2011). Synthesis and characterizations of macroporous poly(acrylamide-2- acrylamido-2-methyl-1-propanesulfonic acid) hydrogels for in vitro drug release of ranitidine hydrochloride. International Journal of Polymeric Materials and Polymeric Biomaterials, 60(7), 490-503. https://doi.org/10.1080/00914037.2010.531816

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title = "Synthesis and characterizations of macroporous poly(acrylamide-2- acrylamido-2-methyl-1-propanesulfonic acid) hydrogels for in vitro drug release of ranitidine hydrochloride",

abstract = "Macroporous hydrogels were prepared with acrylamide (AM) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) as well as with anhydrous dextrose (AD) as porogen by crosslinking with N,N1-methylenebisacrylamide (MBA). The chemical structure of hydrogels is characterized by Fourier transform infrared (FTIR) spectroscopy. Morphological studies done by scanning electron microscopy (SEM) showed the macroporous nature of the hydrogels. Swelling studies of hydrogels were done in distilled water, in aqueous NaCl solution and in different pH solutions. In addition, drug release studies of selected macroporous hydrogels (DAMPS1, DAMPS4, DAMPSM1 and DAMPSM3) are also investigated.",

keywords = "2-acrylamido-2-methyl-l-propanesulfonic acid, anhydrous dextrose, macroporous hydrogels",

author = "K. Varaprasad and Reddy, {N. Narayana} and S. Ravindra and K. Vimala and Raju, {K. Mohana}",

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Varaprasad, K, Reddy, NN, Ravindra, S, Vimala, K & Raju, KM 2011, 'Synthesis and characterizations of macroporous poly(acrylamide-2- acrylamido-2-methyl-1-propanesulfonic acid) hydrogels for in vitro drug release of ranitidine hydrochloride', International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 60, no. 7, pp. 490-503. https://doi.org/10.1080/00914037.2010.531816

Synthesis and characterizations of macroporous poly(acrylamide-2- acrylamido-2-methyl-1-propanesulfonic acid) hydrogels for in vitro drug release of ranitidine hydrochloride. / Varaprasad, K.; Reddy, N. Narayana; Ravindra, S. et al.
In: International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 60, No. 7, 01.2011, p. 490-503.

Research output: Contribution to journal › Article › peer-review

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T1 - Synthesis and characterizations of macroporous poly(acrylamide-2- acrylamido-2-methyl-1-propanesulfonic acid) hydrogels for in vitro drug release of ranitidine hydrochloride

AU - Varaprasad, K.

AU - Reddy, N. Narayana

AU - Ravindra, S.

AU - Vimala, K.

AU - Raju, K. Mohana

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AB - Macroporous hydrogels were prepared with acrylamide (AM) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) as well as with anhydrous dextrose (AD) as porogen by crosslinking with N,N1-methylenebisacrylamide (MBA). The chemical structure of hydrogels is characterized by Fourier transform infrared (FTIR) spectroscopy. Morphological studies done by scanning electron microscopy (SEM) showed the macroporous nature of the hydrogels. Swelling studies of hydrogels were done in distilled water, in aqueous NaCl solution and in different pH solutions. In addition, drug release studies of selected macroporous hydrogels (DAMPS1, DAMPS4, DAMPSM1 and DAMPSM3) are also investigated.

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Synthesis and characterizations of macroporous poly(acrylamide-2- acrylamido-2-methyl-1-propanesulfonic acid) hydrogels for in vitro drug release of ranitidine hydrochloride

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