Studies on curcumin loaded poly(n -isopropylacrylamide) silver nanocomposite hydrogels for antibacterial and drug releasing applications

Sakey Ravindra; Kokkarachedu Varaprasad; V. Rajinikanth; Antoine F. Mulaba-Bafubiandi; Koduri Venkata Surya Ramam

doi:10.1080/10601325.2013.843406

Studies on curcumin loaded poly(n -isopropylacrylamide) silver nanocomposite hydrogels for antibacterial and drug releasing applications

Sakey Ravindra^*, Kokkarachedu Varaprasad, V. Rajinikanth, Antoine F. Mulaba-Bafubiandi, Koduri Venkata Surya Ramam

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Design of silver nanoparticles containing poly(N-isopropylarclamide) (PNIPAAm) hydrogels were prepared by free-radical polymerization of N-isopropylarclamide as an environmentally sensitive monomer and MBA as a crosslinker in an aqueous medium. The embedded silver nanocomposite hydrogels (AgNCH) structure were characterized by, UV-Vis, FTIR, DLS, TEM and X-ray analysis. Curcumin loading and release characteristics were performed for PNIPAAm hydrogel, silver ions loaded hydrogels as well as silver nanocomposite hydrogels. These curcumin loaded silver nanocomposite hydrogels exhibit excellent antibacterial action on Escherichia coli (E. coli). Therefore, the present study clearly provides novel antimicrobial hydrogels which are potentially useful in biomedical applications.

Original language	English
Pages (from-to)	1230-1240
Number of pages	11
Journal	Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume	50
Issue number	12
DOIs	https://doi.org/10.1080/10601325.2013.843406
State	Published - 2013
Externally published	Yes

Bibliographical note

Funding Information:
The authors (SR and AFM-B) thank the University of Johannesburg, South Africa for the partial financial support.

ASJC Scopus subject areas

Ceramics and Composites
General Chemistry
Polymers and Plastics
Materials Chemistry

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10.1080/10601325.2013.843406

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Ravindra, S., Varaprasad, K., Rajinikanth, V., Mulaba-Bafubiandi, A. F., & Venkata Surya Ramam, K. (2013). Studies on curcumin loaded poly(n -isopropylacrylamide) silver nanocomposite hydrogels for antibacterial and drug releasing applications. Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, 50(12), 1230-1240. https://doi.org/10.1080/10601325.2013.843406

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abstract = "Design of silver nanoparticles containing poly(N-isopropylarclamide) (PNIPAAm) hydrogels were prepared by free-radical polymerization of N-isopropylarclamide as an environmentally sensitive monomer and MBA as a crosslinker in an aqueous medium. The embedded silver nanocomposite hydrogels (AgNCH) structure were characterized by, UV-Vis, FTIR, DLS, TEM and X-ray analysis. Curcumin loading and release characteristics were performed for PNIPAAm hydrogel, silver ions loaded hydrogels as well as silver nanocomposite hydrogels. These curcumin loaded silver nanocomposite hydrogels exhibit excellent antibacterial action on Escherichia coli (E. coli). Therefore, the present study clearly provides novel antimicrobial hydrogels which are potentially useful in biomedical applications.",

keywords = "Silver nanocomposites, antibacterial activity, curcumin, hydrogels",

author = "Sakey Ravindra and Kokkarachedu Varaprasad and V. Rajinikanth and Mulaba-Bafubiandi, {Antoine F.} and {Venkata Surya Ramam}, Koduri",

note = "Funding Information: The authors (SR and AFM-B) thank the University of Johannesburg, South Africa for the partial financial support.",

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Ravindra, S, Varaprasad, K, Rajinikanth, V, Mulaba-Bafubiandi, AF & Venkata Surya Ramam, K 2013, 'Studies on curcumin loaded poly(n -isopropylacrylamide) silver nanocomposite hydrogels for antibacterial and drug releasing applications', Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, vol. 50, no. 12, pp. 1230-1240. https://doi.org/10.1080/10601325.2013.843406

Studies on curcumin loaded poly(n -isopropylacrylamide) silver nanocomposite hydrogels for antibacterial and drug releasing applications. / Ravindra, Sakey; Varaprasad, Kokkarachedu; Rajinikanth, V. et al.
In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, Vol. 50, No. 12, 01.01.2013, p. 1230-1240.

Research output: Contribution to journal › Article › peer-review

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T1 - Studies on curcumin loaded poly(n -isopropylacrylamide) silver nanocomposite hydrogels for antibacterial and drug releasing applications

AU - Ravindra, Sakey

AU - Varaprasad, Kokkarachedu

AU - Rajinikanth, V.

AU - Mulaba-Bafubiandi, Antoine F.

AU - Venkata Surya Ramam, Koduri

N1 - Funding Information: The authors (SR and AFM-B) thank the University of Johannesburg, South Africa for the partial financial support.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Design of silver nanoparticles containing poly(N-isopropylarclamide) (PNIPAAm) hydrogels were prepared by free-radical polymerization of N-isopropylarclamide as an environmentally sensitive monomer and MBA as a crosslinker in an aqueous medium. The embedded silver nanocomposite hydrogels (AgNCH) structure were characterized by, UV-Vis, FTIR, DLS, TEM and X-ray analysis. Curcumin loading and release characteristics were performed for PNIPAAm hydrogel, silver ions loaded hydrogels as well as silver nanocomposite hydrogels. These curcumin loaded silver nanocomposite hydrogels exhibit excellent antibacterial action on Escherichia coli (E. coli). Therefore, the present study clearly provides novel antimicrobial hydrogels which are potentially useful in biomedical applications.

AB - Design of silver nanoparticles containing poly(N-isopropylarclamide) (PNIPAAm) hydrogels were prepared by free-radical polymerization of N-isopropylarclamide as an environmentally sensitive monomer and MBA as a crosslinker in an aqueous medium. The embedded silver nanocomposite hydrogels (AgNCH) structure were characterized by, UV-Vis, FTIR, DLS, TEM and X-ray analysis. Curcumin loading and release characteristics were performed for PNIPAAm hydrogel, silver ions loaded hydrogels as well as silver nanocomposite hydrogels. These curcumin loaded silver nanocomposite hydrogels exhibit excellent antibacterial action on Escherichia coli (E. coli). Therefore, the present study clearly provides novel antimicrobial hydrogels which are potentially useful in biomedical applications.

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Studies on curcumin loaded poly(n -isopropylacrylamide) silver nanocomposite hydrogels for antibacterial and drug releasing applications

Abstract

Bibliographical note

ASJC Scopus subject areas

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