Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity

Olga L. Cifuentes-Vaca; Juan Andrades-Lagos; Javier Campanini-Salinas; Antonio Laguna; David Vásquez-Velásquez; M. Concepción Gimeno

doi:10.1016/j.ica.2019.02.033

Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity

Olga L. Cifuentes-Vaca
, Juan Andrades-Lagos
, Javier Campanini-Salinas
, Antonio Laguna
, David Vásquez-Velásquez
, M. Concepción Gimeno^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

By reaction of 2-aminofluorene with 2-pyridinecarboxaldehyde a new Schiff base (L) is obtained. The reaction of this ligand with Ag(I) and Cu(I) salts in different stoichiometry leads to the complexes [Ag(CF₃SO₃)(L)PPh₃] (1) or [ML₂]A (M = Ag, Cu; A = CF₃SO₃, ClO₄ or BF₄). Structural characterization by X-ray crystallography has been carried out for complexes [AgL₂]ClO₄ (4) and [Ag(L)(PPh₃)₂](CF₃SO₃) (6), which confirms the chelate nature of L and the presence of Ag⋯H interactions between two molecules. The biological studies show that Schiff base L presents antibacterial activity in Gram-positive bacteria and E. coli. The coordination to silver increases this activity, but the formation of the copper complex does not generate significant changes.

Original language	English
Pages (from-to)	275-279
Number of pages	5
Journal	Inorganica Chimica Acta
Volume	489
DOIs	https://doi.org/10.1016/j.ica.2019.02.033
State	Published - 2019

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Publisher Copyright:
© 2019

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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@article{4d4895f9cab848ec82a3f17c44d1cada,

title = "Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity",

abstract = "By reaction of 2-aminofluorene with 2-pyridinecarboxaldehyde a new Schiff base (L) is obtained. The reaction of this ligand with Ag(I) and Cu(I) salts in different stoichiometry leads to the complexes [Ag(CF3SO3)(L)PPh3] (1) or [ML2]A (M = Ag, Cu; A = CF3SO3, ClO4 or BF4). Structural characterization by X-ray crystallography has been carried out for complexes [AgL2]ClO4 (4) and [Ag(L)(PPh3)2](CF3SO3) (6), which confirms the chelate nature of L and the presence of Ag⋯H interactions between two molecules. The biological studies show that Schiff base L presents antibacterial activity in Gram-positive bacteria and E. coli. The coordination to silver increases this activity, but the formation of the copper complex does not generate significant changes.",

author = "Cifuentes-Vaca, \{Olga L.\} and Juan Andrades-Lagos and Javier Campanini-Salinas and Antonio Laguna and David V{\'a}squez-Vel{\'a}squez and \{Concepci{\'o}n Gimeno\}, M.",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = apr,

day = "1",

doi = "10.1016/j.ica.2019.02.033",

language = "English",

volume = "489",

pages = "275--279",

journal = "Inorganica Chimica Acta",

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TY - JOUR

T1 - Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity

AU - Cifuentes-Vaca, Olga L.

AU - Andrades-Lagos, Juan

AU - Campanini-Salinas, Javier

AU - Laguna, Antonio

AU - Vásquez-Velásquez, David

AU - Concepción Gimeno, M.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - By reaction of 2-aminofluorene with 2-pyridinecarboxaldehyde a new Schiff base (L) is obtained. The reaction of this ligand with Ag(I) and Cu(I) salts in different stoichiometry leads to the complexes [Ag(CF3SO3)(L)PPh3] (1) or [ML2]A (M = Ag, Cu; A = CF3SO3, ClO4 or BF4). Structural characterization by X-ray crystallography has been carried out for complexes [AgL2]ClO4 (4) and [Ag(L)(PPh3)2](CF3SO3) (6), which confirms the chelate nature of L and the presence of Ag⋯H interactions between two molecules. The biological studies show that Schiff base L presents antibacterial activity in Gram-positive bacteria and E. coli. The coordination to silver increases this activity, but the formation of the copper complex does not generate significant changes.

AB - By reaction of 2-aminofluorene with 2-pyridinecarboxaldehyde a new Schiff base (L) is obtained. The reaction of this ligand with Ag(I) and Cu(I) salts in different stoichiometry leads to the complexes [Ag(CF3SO3)(L)PPh3] (1) or [ML2]A (M = Ag, Cu; A = CF3SO3, ClO4 or BF4). Structural characterization by X-ray crystallography has been carried out for complexes [AgL2]ClO4 (4) and [Ag(L)(PPh3)2](CF3SO3) (6), which confirms the chelate nature of L and the presence of Ag⋯H interactions between two molecules. The biological studies show that Schiff base L presents antibacterial activity in Gram-positive bacteria and E. coli. The coordination to silver increases this activity, but the formation of the copper complex does not generate significant changes.

UR - https://www.scopus.com/pages/publications/85062209721

U2 - 10.1016/j.ica.2019.02.033

DO - 10.1016/j.ica.2019.02.033

M3 - Article

AN - SCOPUS:85062209721

SN - 0020-1693

VL - 489

SP - 275

EP - 279

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity

Abstract

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ASJC Scopus subject areas

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