TY - JOUR
T1 - Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity
AU - Cifuentes-Vaca, Olga L.
AU - Andrades-Lagos, Juan
AU - Campanini-Salinas, Javier
AU - Laguna, Antonio
AU - Vásquez-Velásquez, David
AU - Concepción Gimeno, M.
N1 - Publisher Copyright:
© 2019
PY - 2019/4/1
Y1 - 2019/4/1
N2 - By reaction of 2-aminofluorene with 2-pyridinecarboxaldehyde a new Schiff base (L) is obtained. The reaction of this ligand with Ag(I) and Cu(I) salts in different stoichiometry leads to the complexes [Ag(CF3SO3)(L)PPh3] (1) or [ML2]A (M = Ag, Cu; A = CF3SO3, ClO4 or BF4). Structural characterization by X-ray crystallography has been carried out for complexes [AgL2]ClO4 (4) and [Ag(L)(PPh3)2](CF3SO3) (6), which confirms the chelate nature of L and the presence of Ag⋯H interactions between two molecules. The biological studies show that Schiff base L presents antibacterial activity in Gram-positive bacteria and E. coli. The coordination to silver increases this activity, but the formation of the copper complex does not generate significant changes.
AB - By reaction of 2-aminofluorene with 2-pyridinecarboxaldehyde a new Schiff base (L) is obtained. The reaction of this ligand with Ag(I) and Cu(I) salts in different stoichiometry leads to the complexes [Ag(CF3SO3)(L)PPh3] (1) or [ML2]A (M = Ag, Cu; A = CF3SO3, ClO4 or BF4). Structural characterization by X-ray crystallography has been carried out for complexes [AgL2]ClO4 (4) and [Ag(L)(PPh3)2](CF3SO3) (6), which confirms the chelate nature of L and the presence of Ag⋯H interactions between two molecules. The biological studies show that Schiff base L presents antibacterial activity in Gram-positive bacteria and E. coli. The coordination to silver increases this activity, but the formation of the copper complex does not generate significant changes.
UR - http://www.scopus.com/inward/record.url?scp=85062209721&partnerID=8YFLogxK
U2 - 10.1016/j.ica.2019.02.033
DO - 10.1016/j.ica.2019.02.033
M3 - Article
AN - SCOPUS:85062209721
SN - 0020-1693
VL - 489
SP - 275
EP - 279
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
ER -