Scavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture

B. Godoy; P. Murgas; J. Tichauer; R. Von Bernhardi

doi:10.1016/j.jneuroim.2012.06.004

Scavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture

B. Godoy
, P. Murgas
, J. Tichauer
, R. Von Bernhardi^*

^*Corresponding author for this work

Pontificia Universidad Católica de Chile

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-κB signaling and increased production of IL1β and nitric oxide (NO). IL1β classically an inflammatory cytokine surprisingly did not increase but inhibited LPS + IFNγ-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation.

Original language	English
Pages (from-to)	6-13
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	251
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2012.06.004
State	Published - 2012
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by grant Fondecyt 1090353 (RvB) and grant NIH R03 TW008019 . We thank Dr. Lisette Leyton for providing the cell line DI-TNC1. We thank Gigliola Ramírez for excellent technical help.

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2012.06.004

Cite this

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title = "Scavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture",

abstract = "Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-κB signaling and increased production of IL1β and nitric oxide (NO). IL1β classically an inflammatory cytokine surprisingly did not increase but inhibited LPS + IFNγ-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation.",

keywords = "Glia, IL1β, MAPK, NFκB, Neuroinflammation, SR-As",

author = "B. Godoy and P. Murgas and J. Tichauer and \{Von Bernhardi\}, R.",

note = "Funding Information: This work was supported by grant Fondecyt 1090353 (RvB) and grant NIH R03 TW008019 . We thank Dr. Lisette Leyton for providing the cell line DI-TNC1. We thank Gigliola Ram{\'i}rez for excellent technical help.",

year = "2012",

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doi = "10.1016/j.jneuroim.2012.06.004",

language = "English",

volume = "251",

pages = "6--13",

journal = "Journal of Neuroimmunology",

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T1 - Scavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture

AU - Godoy, B.

AU - Murgas, P.

AU - Tichauer, J.

AU - Von Bernhardi, R.

N1 - Funding Information: This work was supported by grant Fondecyt 1090353 (RvB) and grant NIH R03 TW008019 . We thank Dr. Lisette Leyton for providing the cell line DI-TNC1. We thank Gigliola Ramírez for excellent technical help.

PY - 2012/10/15

Y1 - 2012/10/15

N2 - Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-κB signaling and increased production of IL1β and nitric oxide (NO). IL1β classically an inflammatory cytokine surprisingly did not increase but inhibited LPS + IFNγ-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation.

AB - Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-κB signaling and increased production of IL1β and nitric oxide (NO). IL1β classically an inflammatory cytokine surprisingly did not increase but inhibited LPS + IFNγ-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation.

KW - Glia

KW - IL1β

KW - MAPK

KW - NFκB

KW - Neuroinflammation

KW - SR-As

UR - https://www.scopus.com/pages/publications/84865622320

U2 - 10.1016/j.jneuroim.2012.06.004

DO - 10.1016/j.jneuroim.2012.06.004

M3 - Article

C2 - 22743055

AN - SCOPUS:84865622320

SN - 0165-5728

VL - 251

SP - 6

EP - 13

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Scavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture

Abstract

Bibliographical note

ASJC Scopus subject areas

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