Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico

Translated title of the contribution: The role of intestinal microbiota in the development of non-alcoholic fatty liver disease

María Fernanda Tumani, Gladys Tapia, Carolina Aguirre, Ana María Obregón, Paulina Pettinelli*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of hepatic pathologies ranging from simple steatosis (SS) to hepatocellular carcinoma. Intestinal microbiota (IM) is composed of trillions of microorganisms existing in the gut. It has 150 times more genes than the host. Changes in the composition and function of the IM are associated with different diseases, including NAFLD. In this condition, IM could have a pathogenic role through different mechanisms such as energy salvaging from food, an inflammatory stimulus, a modulation of the innate immune system, regulation of bile acid turnover, alteration of choline metabolism and increasing endogenous ethanol levels. This review is an update on the role of the intestinal microbiota in NAFLD and the possible mechanisms involved.

Translated title of the contributionThe role of intestinal microbiota in the development of non-alcoholic fatty liver disease
Original languageSpanish
Pages (from-to)570-579
Number of pages10
JournalRevista Medica de Chile
Volume149
Issue number4
DOIs
StatePublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 Sociedad Medica de Santiago. All rights reserved.

ASJC Scopus subject areas

  • General Medicine

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