TY - JOUR
T1 - Regulation of cardiomyocyte autophagy by calcium
AU - Shaikh, Soni
AU - Troncoso, Rodrigo
AU - Criollo, Alfredo
AU - Bravo-Sagua, Roberto
AU - García, Lorena
AU - Morselli, Eugenia
AU - Cifuentes, Mariana
AU - Quest, Andrew F.G.
AU - Hill, Joseph A.
AU - Lavandero, Sergio
N1 - Publisher Copyright:
© 2016 the American Physiological Society.
PY - 2016/4/15
Y1 - 2016/4/15
N2 - Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.
AB - Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.
KW - Autophagy
KW - Calcium
KW - Cardiomyocyte
KW - Heart
KW - Interorganelle communication
UR - https://www.scopus.com/pages/publications/84983786855
U2 - 10.1152/ajpendo.00374.2015
DO - 10.1152/ajpendo.00374.2015
M3 - Review article
C2 - 26884385
AN - SCOPUS:84983786855
SN - 0193-1849
VL - 310
SP - E587-E596
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
IS - 8
ER -
