Near-critical GLUT1 and Neurodegeneration

L. Felipe Barros; Alejandro San Martín; Ivan Ruminot; Pamela Y. Sandoval; Ignacio Fernández-Moncada; Felipe Baeza-Lehnert; Robinson Arce-Molina; Yasna Contreras-Baeza; Francisca Cortés-Molina; Alex Galaz; Karin Alegría

doi:10.1002/jnr.23998

Near-critical GLUT1 and Neurodegeneration

L. Felipe Barros^*, Alejandro San Martín, Ivan Ruminot, Pamela Y. Sandoval, Ignacio Fernández-Moncada, Felipe Baeza-Lehnert, Robinson Arce-Molina, Yasna Contreras-Baeza, Francisca Cortés-Molina, Alex Galaz, Karin Alegría

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Recent articles have drawn renewed attention to the housekeeping glucose transporter GLUT1 and its possible involvement in neurodegenerative diseases. Here we provide an updated analysis of brain glucose transport and the cellular mechanisms involved in its acute modulation during synaptic activity. We discuss how the architecture of the blood-brain barrier and the low concentration of glucose within neurons combine to make endothelial/glial GLUT1 the master controller of neuronal glucose utilization, while the regulatory role of the neuronal glucose transporter GLUT3 emerges as secondary. The near-critical condition of glucose dynamics in the brain suggests that subtle deficits in GLUT1 function or its activity-dependent control by neurons may contribute to neurodegeneration.

Original language	English
Pages (from-to)	2267-2274
Number of pages	8
Journal	Journal of Neuroscience Research
Volume	95
Issue number	11
DOIs	https://doi.org/10.1002/jnr.23998
State	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

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10.1002/jnr.23998

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title = "Near-critical GLUT1 and Neurodegeneration",

abstract = "Recent articles have drawn renewed attention to the housekeeping glucose transporter GLUT1 and its possible involvement in neurodegenerative diseases. Here we provide an updated analysis of brain glucose transport and the cellular mechanisms involved in its acute modulation during synaptic activity. We discuss how the architecture of the blood-brain barrier and the low concentration of glucose within neurons combine to make endothelial/glial GLUT1 the master controller of neuronal glucose utilization, while the regulatory role of the neuronal glucose transporter GLUT3 emerges as secondary. The near-critical condition of glucose dynamics in the brain suggests that subtle deficits in GLUT1 function or its activity-dependent control by neurons may contribute to neurodegeneration.",

keywords = "Alzheimer disease, GLUT1 deficiency, Slc2a1, astrocyte, endothelium, glucose transporter",

author = "Barros, {L. Felipe} and {San Mart{\'i}n}, Alejandro and Ivan Ruminot and Sandoval, {Pamela Y.} and Ignacio Fern{\'a}ndez-Moncada and Felipe Baeza-Lehnert and Robinson Arce-Molina and Yasna Contreras-Baeza and Francisca Cort{\'e}s-Molina and Alex Galaz and Karin Alegr{\'i}a",

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doi = "10.1002/jnr.23998",

language = "English",

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AU - Barros, L. Felipe

AU - San Martín, Alejandro

AU - Ruminot, Ivan

AU - Sandoval, Pamela Y.

AU - Fernández-Moncada, Ignacio

AU - Baeza-Lehnert, Felipe

AU - Arce-Molina, Robinson

AU - Contreras-Baeza, Yasna

AU - Cortés-Molina, Francisca

AU - Galaz, Alex

AU - Alegría, Karin

PY - 2017/11

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N2 - Recent articles have drawn renewed attention to the housekeeping glucose transporter GLUT1 and its possible involvement in neurodegenerative diseases. Here we provide an updated analysis of brain glucose transport and the cellular mechanisms involved in its acute modulation during synaptic activity. We discuss how the architecture of the blood-brain barrier and the low concentration of glucose within neurons combine to make endothelial/glial GLUT1 the master controller of neuronal glucose utilization, while the regulatory role of the neuronal glucose transporter GLUT3 emerges as secondary. The near-critical condition of glucose dynamics in the brain suggests that subtle deficits in GLUT1 function or its activity-dependent control by neurons may contribute to neurodegeneration.

AB - Recent articles have drawn renewed attention to the housekeeping glucose transporter GLUT1 and its possible involvement in neurodegenerative diseases. Here we provide an updated analysis of brain glucose transport and the cellular mechanisms involved in its acute modulation during synaptic activity. We discuss how the architecture of the blood-brain barrier and the low concentration of glucose within neurons combine to make endothelial/glial GLUT1 the master controller of neuronal glucose utilization, while the regulatory role of the neuronal glucose transporter GLUT3 emerges as secondary. The near-critical condition of glucose dynamics in the brain suggests that subtle deficits in GLUT1 function or its activity-dependent control by neurons may contribute to neurodegeneration.

KW - Alzheimer disease

KW - GLUT1 deficiency

KW - Slc2a1

KW - astrocyte

KW - endothelium

KW - glucose transporter

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EP - 2274

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

IS - 11

ER -

Near-critical GLUT1 and Neurodegeneration

Abstract

Bibliographical note

ASJC Scopus subject areas

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