TY - JOUR
T1 - Natural essential oils as a new therapeutic tool in colorectal cancer
AU - Garzoli, Stefania
AU - Alarcón-Zapata, Pedro
AU - Seitimova, Gulnaz
AU - Alarcón-Zapata, Barbara
AU - Martorell, Miquel
AU - Sharopov, Farukh
AU - Fokou, Patrick Valere Tsouh
AU - Dize, Darline
AU - Yamthe, Lauve Rachel Tchokouaha
AU - Les, Francisco
AU - Cásedas, Guillermo
AU - López, Víctor
AU - Iriti, Marcello
AU - Rad, Javad Sharifi
AU - Gürer, Eda Sönmez
AU - Calina, Daniela
AU - Pezzani, Raffaele
AU - Vitalini, Sara
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Colorectal cancer (CRC) is the third most revalent type of cancer in the world and the second most common cause of cancer death (about 1 million per year). Historically, natural compounds and their structural analogues have contributed to the development of new drugs useful in the treatment of various diseases, including cancer. Essential oils are natural odorous products made up of a complex mixture of low molecular weight compounds with recognized biological and pharmacological properties investigated also for the prevention and treatment of cancer. The aim of this paper is to highlight the possible role of essential oils in CRC, their composition and the preclinical studies involving them. It has been reviewed the preclinical pharmacological studies to determine the experimental models used and the anticancer potential mechanisms of action of natural essential oils in CRC. Searches were performed in the following databases PubMed/Medline, Web of science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. The results of analyzed studies showed that EOs exhibited a wide range of bioactive effects like cytotoxicity, antiproliferative, and antimetastatic effects on cancer cells through various mechanisms of action. This updated review provides a better quality of scientific evidence for the efficacy of EOs as chemotherapeutic/chemopreventive agents in CRC. Future translational clinical studies are needed to establish the effective dose in humans as well as the most suitable route of administration for maximum bioavailability and efficacy. Given the positive anticancer results obtained from preclinical pharmacological studies, EOs can be considered efficient complementary therapies in chemotherapy in CRC.
AB - Colorectal cancer (CRC) is the third most revalent type of cancer in the world and the second most common cause of cancer death (about 1 million per year). Historically, natural compounds and their structural analogues have contributed to the development of new drugs useful in the treatment of various diseases, including cancer. Essential oils are natural odorous products made up of a complex mixture of low molecular weight compounds with recognized biological and pharmacological properties investigated also for the prevention and treatment of cancer. The aim of this paper is to highlight the possible role of essential oils in CRC, their composition and the preclinical studies involving them. It has been reviewed the preclinical pharmacological studies to determine the experimental models used and the anticancer potential mechanisms of action of natural essential oils in CRC. Searches were performed in the following databases PubMed/Medline, Web of science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. The results of analyzed studies showed that EOs exhibited a wide range of bioactive effects like cytotoxicity, antiproliferative, and antimetastatic effects on cancer cells through various mechanisms of action. This updated review provides a better quality of scientific evidence for the efficacy of EOs as chemotherapeutic/chemopreventive agents in CRC. Future translational clinical studies are needed to establish the effective dose in humans as well as the most suitable route of administration for maximum bioavailability and efficacy. Given the positive anticancer results obtained from preclinical pharmacological studies, EOs can be considered efficient complementary therapies in chemotherapy in CRC.
KW - Anticancer properties
KW - Anticancer therapy
KW - Apoptosis
KW - Colorectal cancer
KW - Cytotoxicity
KW - Natural essential oils
UR - http://www.scopus.com/inward/record.url?scp=85144031235&partnerID=8YFLogxK
U2 - 10.1186/s12935-022-02806-5
DO - 10.1186/s12935-022-02806-5
M3 - Review article
AN - SCOPUS:85144031235
SN - 1475-2867
VL - 22
JO - Cancer Cell International
JF - Cancer Cell International
IS - 1
M1 - 407
ER -