MOBI: A web server to define and visualize structural mobility in NMR protein ensembles

Alberto J.M. Martin; Ian Walsh; Silvio C.E. Tosatto

doi:10.1093/bioinformatics/btq537

MOBI: A web server to define and visualize structural mobility in NMR protein ensembles

Alberto J.M. Martin, Ian Walsh, Silvio C.E. Tosatto^*

^*Corresponding author for this work

University of Padua

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Motivation: MOBI is a web server for the identification of structurally mobile regions in NMR protein ensembles. It provides a binary mobility definition that is analogous to the commonly used definition of intrinsic disorder in X-ray crystallographic structures. At least three different use cases can be envisaged: (i) visualization of NMR mobility for structural analysis; (ii) definition of regions for reliable comparative modelling in protein structure prediction and (iii) definition of mobility in analogy to intrinsic disorder. MOBI uses structural superposition and local conformational differences to derive a robust binary mobility definition that is in excellent agreement with the manually curated definition used in the CASP8 experiment for intrinsic disorder in NMR structure. The output includes mobility-coloured PDB files, mobility plots and a FASTA formatted sequence file summarizing the mobility results.

Original language	English
Article number	btq537
Pages (from-to)	2916-2917
Number of pages	2
Journal	Bioinformatics
Volume	26
Issue number	22
DOIs	https://doi.org/10.1093/bioinformatics/btq537
State	Published - 2010
Externally published	Yes

Bibliographical note

Funding Information:
Funding: University of Padova grants (CPDA098382 to S.T. and CPDR097328 to A.M. and S.T.).

ASJC Scopus subject areas

Statistics and Probability
Biochemistry
Molecular Biology
Computer Science Applications
Computational Theory and Mathematics
Computational Mathematics

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Cite this

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title = "MOBI: A web server to define and visualize structural mobility in NMR protein ensembles",

abstract = "Motivation: MOBI is a web server for the identification of structurally mobile regions in NMR protein ensembles. It provides a binary mobility definition that is analogous to the commonly used definition of intrinsic disorder in X-ray crystallographic structures. At least three different use cases can be envisaged: (i) visualization of NMR mobility for structural analysis; (ii) definition of regions for reliable comparative modelling in protein structure prediction and (iii) definition of mobility in analogy to intrinsic disorder. MOBI uses structural superposition and local conformational differences to derive a robust binary mobility definition that is in excellent agreement with the manually curated definition used in the CASP8 experiment for intrinsic disorder in NMR structure. The output includes mobility-coloured PDB files, mobility plots and a FASTA formatted sequence file summarizing the mobility results.",

author = "Martin, {Alberto J.M.} and Ian Walsh and Tosatto, {Silvio C.E.}",

note = "Funding Information: Funding: University of Padova grants (CPDA098382 to S.T. and CPDR097328 to A.M. and S.T.).",

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AU - Walsh, Ian

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MOBI: A web server to define and visualize structural mobility in NMR protein ensembles

Abstract

Bibliographical note

ASJC Scopus subject areas

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