KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover

Diego Tapia; Tomás Jiménez; Constanza Zamora; Javier Espinoza; Riccardo Rizzo; Alexis González-Cárdenas; Danitza Fuentes; Sergio Hernández; Viviana A. Cavieres; Andrea Soza; Fanny Guzmán; Gloria Arriagada; María Isabel Yuseff; Gonzalo A. Mardones; Patricia V. Burgos; Alberto Luini; Alfonso González; Jorge Cancino

doi:10.1038/s41467-019-08501-w

KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover

Diego Tapia, Tomás Jiménez, Constanza Zamora, Javier Espinoza, Riccardo Rizzo, Alexis González-Cárdenas, Danitza Fuentes, Sergio Hernández, Viviana A. Cavieres, Andrea Soza, Fanny Guzmán, Gloria Arriagada, María Isabel Yuseff, Gonzalo A. Mardones, Patricia V. Burgos, Alberto Luini, Alfonso González, Jorge Cancino^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Inter-organelle signalling has essential roles in cell physiology encompassing cell metabolism, aging and temporal adaptation to external and internal perturbations. How such signalling coordinates different organelle functions within adaptive responses remains unknown. Membrane traffic is a fundamental process in which membrane fluxes need to be sensed for the adjustment of cellular requirements and homeostasis. Studying endoplasmic reticulum-to-Golgi trafficking, we found that Golgi-based, KDEL receptor-dependent signalling promotes lysosome repositioning to the perinuclear area, involving a complex process intertwined to autophagy, lipid-droplet turnover and Golgi-mediated secretion that engages the microtubule motor protein dynein-LRB1 and the autophagy cargo receptor p62/SQSTM1. This process, here named ‘traffic-induced degradation response for secretion’ (TIDeRS) discloses a cellular mechanism by which nutrient and membrane sensing machineries cooperate to sustain Golgi-dependent protein secretion.

Original language	English
Article number	735
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-08501-w
State	Published - 2019

Bibliographical note

Publisher Copyright:
© 2019, The Author(s).

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Tapia, D., Jiménez, T., Zamora, C., Espinoza, J., Rizzo, R., González-Cárdenas, A., Fuentes, D., Hernández, S., Cavieres, V. A., Soza, A., Guzmán, F., Arriagada, G., Yuseff, M. I., Mardones, G. A., Burgos, P. V., Luini, A., González, A., & Cancino, J. (2019). KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover. Nature Communications, 10(1), Article 735. https://doi.org/10.1038/s41467-019-08501-w

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title = "KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover",

abstract = "Inter-organelle signalling has essential roles in cell physiology encompassing cell metabolism, aging and temporal adaptation to external and internal perturbations. How such signalling coordinates different organelle functions within adaptive responses remains unknown. Membrane traffic is a fundamental process in which membrane fluxes need to be sensed for the adjustment of cellular requirements and homeostasis. Studying endoplasmic reticulum-to-Golgi trafficking, we found that Golgi-based, KDEL receptor-dependent signalling promotes lysosome repositioning to the perinuclear area, involving a complex process intertwined to autophagy, lipid-droplet turnover and Golgi-mediated secretion that engages the microtubule motor protein dynein-LRB1 and the autophagy cargo receptor p62/SQSTM1. This process, here named {\textquoteleft}traffic-induced degradation response for secretion{\textquoteright} (TIDeRS) discloses a cellular mechanism by which nutrient and membrane sensing machineries cooperate to sustain Golgi-dependent protein secretion.",

author = "Diego Tapia and Tom{\'a}s Jim{\'e}nez and Constanza Zamora and Javier Espinoza and Riccardo Rizzo and Alexis Gonz{\'a}lez-C{\'a}rdenas and Danitza Fuentes and Sergio Hern{\'a}ndez and Cavieres, {Viviana A.} and Andrea Soza and Fanny Guzm{\'a}n and Gloria Arriagada and Yuseff, {Mar{\'i}a Isabel} and Mardones, {Gonzalo A.} and Burgos, {Patricia V.} and Alberto Luini and Alfonso Gonz{\'a}lez and Jorge Cancino",

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doi = "10.1038/s41467-019-08501-w",

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Tapia, D, Jiménez, T, Zamora, C, Espinoza, J, Rizzo, R, González-Cárdenas, A, Fuentes, D, Hernández, S, Cavieres, VA, Soza, A, Guzmán, F, Arriagada, G, Yuseff, MI, Mardones, GA , Burgos, PV, Luini, A, González, A & Cancino, J 2019, 'KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover', Nature Communications, vol. 10, no. 1, 735. https://doi.org/10.1038/s41467-019-08501-w

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AU - Tapia, Diego

AU - Jiménez, Tomás

AU - Zamora, Constanza

AU - Espinoza, Javier

AU - Rizzo, Riccardo

AU - González-Cárdenas, Alexis

AU - Fuentes, Danitza

AU - Hernández, Sergio

AU - Cavieres, Viviana A.

AU - Soza, Andrea

AU - Guzmán, Fanny

AU - Arriagada, Gloria

AU - Yuseff, María Isabel

AU - Mardones, Gonzalo A.

AU - Burgos, Patricia V.

AU - Luini, Alberto

AU - González, Alfonso

AU - Cancino, Jorge

PY - 2019/12/1

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KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover

Abstract

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