Inspiratory muscle dysfunction and unexplained dyspnea in systemic lupus erythematosus

Sergio Jacobelli*, Rodrigo Moreno, Loreto Massardo, Santiago Rivero, Carmen Lisboa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The role of inspiratory muscle dysfunction in lung volume restriction and unexplained dyspnea was studied in 16 consecutive patients with systemic lupus erythematosus. Maximal mouth inspiratory pressure (PIM) and maximal transdiaphragmatic pressure (Pdi max) were measured. Pdi and its components were determined during quiet breathing. No significant association was found between the activity of the disease, several serologic markers, and the inspiratory muscle dysfunction. No specific anti‐skeletal muscle antibody was found in these patients. Significant correlations were found between the degree of dyspnea and PIM (r = −0.69, P < 0.01) and Pdi max (r = −0.75, P < 0.001); however, dyspnea did not correlate with specific lung compliance. Vital capacity correlated significantly with the degree of dyspnea (r = −0.813, P < 0.001) and with Pdi max (r = 0.544, P < 0.05). No correlation was found between vital capacity and specific lung compliance. We conclude that inspiratory muscle dysfunction can be an important mechanism in the pathogenesis of the lung volume restriction and dyspnea in patients with systemic lupus erythematosus.

Original languageEnglish
Pages (from-to)781-788
Number of pages8
JournalArthritis and Rheumatism
Volume28
Issue number7
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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