HIV/SIV-Nef: Pas de trois Choreographies to Evade Immunity

Luis L.P. daSilva; Gonzalo A. Mardones

doi:10.1016/j.tim.2018.09.003

HIV/SIV-Nef: Pas de trois Choreographies to Evade Immunity

Luis L.P. daSilva^*, Gonzalo A. Mardones

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Nef is a major pathogenic factor of human and simian immunodeficiency viruses that hijacks protein trafficking through physical interaction with vesicle coats. This alters the subcellular localization of proteins involved in immunity and neutralizes their function. Understanding the structural bases for these interactions could reveal new targets for antiviral intervention.

Original language	English
Pages (from-to)	889-891
Number of pages	3
Journal	Trends in Microbiology
Volume	26
Issue number	11
DOIs	https://doi.org/10.1016/j.tim.2018.09.003
State	Published - 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tim.2018.09.003

Cite this

@article{48beec672d894bebadfda2fcb20d8056,

title = "HIV/SIV-Nef: Pas de trois Choreographies to Evade Immunity",

abstract = "Nef is a major pathogenic factor of human and simian immunodeficiency viruses that hijacks protein trafficking through physical interaction with vesicle coats. This alters the subcellular localization of proteins involved in immunity and neutralizes their function. Understanding the structural bases for these interactions could reveal new targets for antiviral intervention.",

keywords = "AP-1, HIV, MHC-I, Nef, SIV, tetherin",

author = "daSilva, {Luis L.P.} and Mardones, {Gonzalo A.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = nov,

doi = "10.1016/j.tim.2018.09.003",

language = "English",

volume = "26",

pages = "889--891",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier Ltd.",

number = "11",

}

TY - JOUR

T1 - HIV/SIV-Nef

T2 - Pas de trois Choreographies to Evade Immunity

AU - daSilva, Luis L.P.

AU - Mardones, Gonzalo A.

PY - 2018/11

Y1 - 2018/11

N2 - Nef is a major pathogenic factor of human and simian immunodeficiency viruses that hijacks protein trafficking through physical interaction with vesicle coats. This alters the subcellular localization of proteins involved in immunity and neutralizes their function. Understanding the structural bases for these interactions could reveal new targets for antiviral intervention.

AB - Nef is a major pathogenic factor of human and simian immunodeficiency viruses that hijacks protein trafficking through physical interaction with vesicle coats. This alters the subcellular localization of proteins involved in immunity and neutralizes their function. Understanding the structural bases for these interactions could reveal new targets for antiviral intervention.

KW - AP-1

KW - HIV

KW - MHC-I

KW - Nef

KW - SIV

KW - tetherin

UR - http://www.scopus.com/inward/record.url?scp=85054151426&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2018.09.003

DO - 10.1016/j.tim.2018.09.003

M3 - Short survey

C2 - 30287212

AN - SCOPUS:85054151426

SN - 0966-842X

VL - 26

SP - 889

EP - 891

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 11

ER -

HIV/SIV-Nef: Pas de trois Choreographies to Evade Immunity

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this