TY - JOUR
T1 - Growth factors and astrocytes metabolism
T2 - Possible roles for platelet derived growth factor
AU - Cabezas, Ricardo
AU - Avila-Rodriguez, Marco
AU - Vega-Vela, Nelson E.
AU - Echeverria, Valentina
AU - González, Janneth
AU - Hidalgo, Oscar A.
AU - Santos, Altair B.
AU - Aliev, Gjumrakch
AU - Barreto, George E.
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Astrocytes exert multiple functions in the brain such as the development of blood-brain barrier characteristics, the promotion of neurovascular coupling, attraction of cells through the release of chemokines, clearance of toxic substances and generation of antioxidant molecules and growth factors. In this aspect, astrocytes secrete several growth factors (BDNF, GDNF, NGF, and others) that are fundamental for cell viability, oxidant protection, genetic expression and modulation of metabolic functions. The platelet derived growth factor (PDGF), which is expressed by many SNC cells, including astrocytes, is an important molecule that has shown neuroprotective potential, improvement of wound healing, regulation of calcium metabolism and mitochondrial function. Here we explore some of these astrocyte-driven functions of growth factors and their possible therapeutic uses in the context of neurodegeneration.
AB - Astrocytes exert multiple functions in the brain such as the development of blood-brain barrier characteristics, the promotion of neurovascular coupling, attraction of cells through the release of chemokines, clearance of toxic substances and generation of antioxidant molecules and growth factors. In this aspect, astrocytes secrete several growth factors (BDNF, GDNF, NGF, and others) that are fundamental for cell viability, oxidant protection, genetic expression and modulation of metabolic functions. The platelet derived growth factor (PDGF), which is expressed by many SNC cells, including astrocytes, is an important molecule that has shown neuroprotective potential, improvement of wound healing, regulation of calcium metabolism and mitochondrial function. Here we explore some of these astrocyte-driven functions of growth factors and their possible therapeutic uses in the context of neurodegeneration.
KW - Astrocyte
KW - Growth factors
KW - Metabolism
KW - Mitochondria
KW - Neuroprotection
KW - Platelet derived growth factor
UR - http://www.scopus.com/inward/record.url?scp=84964758576&partnerID=8YFLogxK
U2 - 10.2174/1573406411666151019120444
DO - 10.2174/1573406411666151019120444
M3 - Article
C2 - 26477707
AN - SCOPUS:84964758576
SN - 1573-4064
VL - 12
SP - 204
EP - 210
JO - Medicinal Chemistry
JF - Medicinal Chemistry
IS - 3
ER -