Glucose and lactate supply to the synapse

L. Felipe Barros; Joachim W. Deitmer

doi:10.1016/j.brainresrev.2009.10.002

Glucose and lactate supply to the synapse

L. Felipe Barros^*, Joachim W. Deitmer

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

127 Scopus citations

Abstract

The main source of energy for the mammalian brain is glucose, and the main sink of energy in the mammalian brain is the neuron, so the conventional view of brain energy metabolism is that glucose is consumed preferentially in neurons. But between glucose and the production of energy are several steps that do not necessarily take place in the same cell. An alternative model has been proposed that states that glucose preferentially taken by astrocytes, is degraded to lactate and then exported into neurons to be oxidized. Short of definitive data, opinions about the relative merits of these competing models are divided, making it a very exciting field of research. Furthermore, growing evidence suggests that lactate acts as a signaling molecule, involved in Na⁺ sensing, glucosensing, and in coupling neuronal and glial activity to the modulation of vascular tone. In the present review, we discuss possible dynamics of glucose and lactate in excitatory synaptic regions, focusing on the transporters that catalyze the movement of these molecules.

Original language	English
Pages (from-to)	149-159
Number of pages	11
Journal	Brain Research Reviews
Volume	63
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainresrev.2009.10.002
State	Published - 2010
Externally published	Yes

Bibliographical note

Funding Information:
We thank Karen Everett for critical reading of the manuscript. This work was supported by a DFG-Conicyt joint grant (to L.F.B. and J.W.D.), by Fondecyt 10070046 to L.F.B and by the Deutsche Forschungsgemeinschaft (DFG), SFB 530 , TP B1 , and 444CHL-113/21/0-1 to J.W. D. The Centro de Estudios Científicos (CECS) is funded by the Chilean Government through the Millennium Science Initiative and the Centers of Excellence Base Financing Program of Conicyt. CECS is also supported by a group of private companies which at present includes Antofagasta Minerals, Arauco, Empresas CMPC, Indura, Naviera Ultragas and Telefónica del Sur. CIN is funded by Conicyt and the Gobierno Regional de Los Ríos.

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1016/j.brainresrev.2009.10.002

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title = "Glucose and lactate supply to the synapse",

abstract = "The main source of energy for the mammalian brain is glucose, and the main sink of energy in the mammalian brain is the neuron, so the conventional view of brain energy metabolism is that glucose is consumed preferentially in neurons. But between glucose and the production of energy are several steps that do not necessarily take place in the same cell. An alternative model has been proposed that states that glucose preferentially taken by astrocytes, is degraded to lactate and then exported into neurons to be oxidized. Short of definitive data, opinions about the relative merits of these competing models are divided, making it a very exciting field of research. Furthermore, growing evidence suggests that lactate acts as a signaling molecule, involved in Na+ sensing, glucosensing, and in coupling neuronal and glial activity to the modulation of vascular tone. In the present review, we discuss possible dynamics of glucose and lactate in excitatory synaptic regions, focusing on the transporters that catalyze the movement of these molecules.",

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author = "Barros, {L. Felipe} and Deitmer, {Joachim W.}",

note = "Funding Information: We thank Karen Everett for critical reading of the manuscript. This work was supported by a DFG-Conicyt joint grant (to L.F.B. and J.W.D.), by Fondecyt 10070046 to L.F.B and by the Deutsche Forschungsgemeinschaft (DFG), SFB 530 , TP B1 , and 444CHL-113/21/0-1 to J.W. D. The Centro de Estudios Cient{\'i}ficos (CECS) is funded by the Chilean Government through the Millennium Science Initiative and the Centers of Excellence Base Financing Program of Conicyt. CECS is also supported by a group of private companies which at present includes Antofagasta Minerals, Arauco, Empresas CMPC, Indura, Naviera Ultragas and Telef{\'o}nica del Sur. CIN is funded by Conicyt and the Gobierno Regional de Los R{\'i}os.",

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Glucose and lactate supply to the synapse

Abstract

Bibliographical note

ASJC Scopus subject areas

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