Evaluation of blood compatibility and drug release studies of gelatin based magnetic hydrogel nanocomposites

N. Narayana Reddy; K. Varaprasad; S. Ravindra; G. V.Subba Reddy; K. M.S. Reddy; K. M. Mohan Reddy; K. Mohana Raju

doi:10.1016/j.colsurfa.2011.05.006

Evaluation of blood compatibility and drug release studies of gelatin based magnetic hydrogel nanocomposites

N. Narayana Reddy, K. Varaprasad, S. Ravindra, G. V.Subba Reddy, K. M.S. Reddy, K. M. Mohan Reddy, K. Mohana Raju^*

^*Corresponding author for this work

Sri Krishnadevaraya University India

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Magnetic nanocomposites are known to possess potential applications due to their superparamagnetic and biocompatible nature. The present work describes the preparation of biocompatible magnetic hydrogel nanocomposites using biocompatible gelatin. The magnetic hydrogels were characterized by using techniques such as FTIR, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and thermal analysis. The swelling analysis of the samples was evaluated. The in vitro biocompatibility of hydrogels was evaluated by performing thrombus formation and haemolysis tests. The presence of biocompatible gelatin in the magnetic hydrogels enhances the water sorption behaviour and in vitro blood compatibility of magnetic nanocomposites. In addition to this the drug releasing studies were performed under external magnetic field. The results indicate that the prepared hydrogels may be useful for potential applications for magnetically controlled drug release-systems, magnetic-sensitive sensors, and pseudomuscular actuators.

Original language	English
Pages (from-to)	20-27
Number of pages	8
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	385
Issue number	1-3
DOIs	https://doi.org/10.1016/j.colsurfa.2011.05.006
State	Published - 2011
Externally published	Yes

Bibliographical note

Funding Information:
The authors (KMR and NNR) thank the University Grants Commission (UGC) Govt. of India, New Delhi, for the partial financial support (UGC Sanction Letter No. F.37-339/2009 (SR) dated 05.01.2010).

ASJC Scopus subject areas

Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

Access to Document

10.1016/j.colsurfa.2011.05.006

Cite this

@article{f4a66e4d281d4afca9e718de809963b3,

title = "Evaluation of blood compatibility and drug release studies of gelatin based magnetic hydrogel nanocomposites",

abstract = "Magnetic nanocomposites are known to possess potential applications due to their superparamagnetic and biocompatible nature. The present work describes the preparation of biocompatible magnetic hydrogel nanocomposites using biocompatible gelatin. The magnetic hydrogels were characterized by using techniques such as FTIR, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and thermal analysis. The swelling analysis of the samples was evaluated. The in vitro biocompatibility of hydrogels was evaluated by performing thrombus formation and haemolysis tests. The presence of biocompatible gelatin in the magnetic hydrogels enhances the water sorption behaviour and in vitro blood compatibility of magnetic nanocomposites. In addition to this the drug releasing studies were performed under external magnetic field. The results indicate that the prepared hydrogels may be useful for potential applications for magnetically controlled drug release-systems, magnetic-sensitive sensors, and pseudomuscular actuators.",

keywords = "Biocompatibility, Bionanocomposites, Drug delivery, Hydrogel, Magnetic properties",

author = "Reddy, {N. Narayana} and K. Varaprasad and S. Ravindra and Reddy, {G. V.Subba} and Reddy, {K. M.S.} and {Mohan Reddy}, {K. M.} and Raju, {K. Mohana}",

note = "Funding Information: The authors (KMR and NNR) thank the University Grants Commission (UGC) Govt. of India, New Delhi, for the partial financial support (UGC Sanction Letter No. F.37-339/2009 (SR) dated 05.01.2010).",

year = "2011",

month = jul,

day = "20",

doi = "10.1016/j.colsurfa.2011.05.006",

language = "English",

volume = "385",

pages = "20--27",

journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",

issn = "0927-7757",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Evaluation of blood compatibility and drug release studies of gelatin based magnetic hydrogel nanocomposites

AU - Reddy, N. Narayana

AU - Varaprasad, K.

AU - Ravindra, S.

AU - Reddy, G. V.Subba

AU - Reddy, K. M.S.

AU - Mohan Reddy, K. M.

AU - Raju, K. Mohana

N1 - Funding Information: The authors (KMR and NNR) thank the University Grants Commission (UGC) Govt. of India, New Delhi, for the partial financial support (UGC Sanction Letter No. F.37-339/2009 (SR) dated 05.01.2010).

PY - 2011/7/20

Y1 - 2011/7/20

N2 - Magnetic nanocomposites are known to possess potential applications due to their superparamagnetic and biocompatible nature. The present work describes the preparation of biocompatible magnetic hydrogel nanocomposites using biocompatible gelatin. The magnetic hydrogels were characterized by using techniques such as FTIR, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and thermal analysis. The swelling analysis of the samples was evaluated. The in vitro biocompatibility of hydrogels was evaluated by performing thrombus formation and haemolysis tests. The presence of biocompatible gelatin in the magnetic hydrogels enhances the water sorption behaviour and in vitro blood compatibility of magnetic nanocomposites. In addition to this the drug releasing studies were performed under external magnetic field. The results indicate that the prepared hydrogels may be useful for potential applications for magnetically controlled drug release-systems, magnetic-sensitive sensors, and pseudomuscular actuators.

AB - Magnetic nanocomposites are known to possess potential applications due to their superparamagnetic and biocompatible nature. The present work describes the preparation of biocompatible magnetic hydrogel nanocomposites using biocompatible gelatin. The magnetic hydrogels were characterized by using techniques such as FTIR, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and thermal analysis. The swelling analysis of the samples was evaluated. The in vitro biocompatibility of hydrogels was evaluated by performing thrombus formation and haemolysis tests. The presence of biocompatible gelatin in the magnetic hydrogels enhances the water sorption behaviour and in vitro blood compatibility of magnetic nanocomposites. In addition to this the drug releasing studies were performed under external magnetic field. The results indicate that the prepared hydrogels may be useful for potential applications for magnetically controlled drug release-systems, magnetic-sensitive sensors, and pseudomuscular actuators.

KW - Biocompatibility

KW - Bionanocomposites

KW - Drug delivery

KW - Hydrogel

KW - Magnetic properties

UR - http://www.scopus.com/inward/record.url?scp=79960624268&partnerID=8YFLogxK

U2 - 10.1016/j.colsurfa.2011.05.006

DO - 10.1016/j.colsurfa.2011.05.006

M3 - Article

AN - SCOPUS:79960624268

SN - 0927-7757

VL - 385

SP - 20

EP - 27

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

IS - 1-3

ER -

Evaluation of blood compatibility and drug release studies of gelatin based magnetic hydrogel nanocomposites

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this