Entrée cellulaire des phlébovirus chez l’hôte mammifère

Translated title of the contribution: Cell biology of phlebovirus entry

Zina M. Uckeley, Jana Koch, Nicole D. Tischler, Psylvia Léger, Pierre Yves Lozach

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Phleboviruses constitute a large group of arthropod-borne viruses (arboviruses), mainly transmitted to their hosts by sandflies and ticks, occasionally by mosquitoes. These viruses have a worldwide distribution and many cause serious diseases - often fatal - in both domestic animals and humans. The global warming, the apparent wide distribution of arthropod reservoirs, and the increasing number of outbreaks show that phleboviruses must be taken seriously as emerging disease agents. This review proposes to focus on the early steps of phlebovirus infection, from virus binding to penetration into the cytosol. We address the most recent knowledge and advances in the entry of these viruses into vertebrate host cells, including virus receptors, cellular factors, endocytic pathways, and fusion.

Translated title of the contributionCell biology of phlebovirus entry
Original languageFrench
Pages (from-to)176-187
Number of pages12
JournalVirologie (Montrouge, France)
Volume23
Issue number3
DOIs
StatePublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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