Emerging role of mitochondrial calcium levels in cellular senescence and in switching cell fates

Céline Margand; Pablo Morgado-Cáceres; Ulises Ahumada-Castro; J. César Cárdenas; Nadine Martin; David Bernard

doi:10.1038/s43587-025-00887-1

Emerging role of mitochondrial calcium levels in cellular senescence and in switching cell fates

Céline Margand
, Pablo Morgado-Cáceres
, Ulises Ahumada-Castro
, J. César Cárdenas
, Nadine Martin
, David Bernard^*

^*Corresponding author for this work

Cancer Research Center of Lyon
Equipe Labellisée la Ligue Contre le Cancer
Universidad Mayor
Geroscience Center for Brain Health and Metabolism

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Manipulating senescent cells by eliminating them or by modifying their activity has attracted huge interest for its potential to delay or even treat many age-related diseases, and to improve healthy aging. Mitochondria, and in particular their calcium levels, have emerged as key regulators of cellular senescence, cell death and the balance between the two, and might constitute targets for novel strategies to stifle the viability or properties of senescent cells.

Original language	English
Article number	6779
Pages (from-to)	1177-1180
Number of pages	4
Journal	Nature Aging
Volume	5
Issue number	7
DOIs	https://doi.org/10.1038/s43587-025-00887-1
State	Published - 2025

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© Springer Nature America, Inc. 2025.

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abstract = "Manipulating senescent cells by eliminating them or by modifying their activity has attracted huge interest for its potential to delay or even treat many age-related diseases, and to improve healthy aging. Mitochondria, and in particular their calcium levels, have emerged as key regulators of cellular senescence, cell death and the balance between the two, and might constitute targets for novel strategies to stifle the viability or properties of senescent cells.",

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AU - Margand, Céline

AU - Morgado-Cáceres, Pablo

AU - Ahumada-Castro, Ulises

AU - Cárdenas, J. César

AU - Martin, Nadine

AU - Bernard, David

PY - 2025/7

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N2 - Manipulating senescent cells by eliminating them or by modifying their activity has attracted huge interest for its potential to delay or even treat many age-related diseases, and to improve healthy aging. Mitochondria, and in particular their calcium levels, have emerged as key regulators of cellular senescence, cell death and the balance between the two, and might constitute targets for novel strategies to stifle the viability or properties of senescent cells.

AB - Manipulating senescent cells by eliminating them or by modifying their activity has attracted huge interest for its potential to delay or even treat many age-related diseases, and to improve healthy aging. Mitochondria, and in particular their calcium levels, have emerged as key regulators of cellular senescence, cell death and the balance between the two, and might constitute targets for novel strategies to stifle the viability or properties of senescent cells.

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Emerging role of mitochondrial calcium levels in cellular senescence and in switching cell fates

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