Dioxin-like compounds bioavailability and genotoxicity assessment in the Gulf of Follonica, Tuscany (Northern Tyrrhenian Sea)

Patrizia Guidi; Simonetta Corsolini; Margherita Bernardeschi; Lucia Rocco; Marco Nigro; Davide Baroni; Filomena Mottola; Vittoria Scarcelli; Marianna Santonastaso; Alessandra Falleni; Camilla Della Torre; Ilaria Corsi; Karla Pozo; Giada Frenzilli

doi:10.1016/j.marpolbul.2017.11.062

Dioxin-like compounds bioavailability and genotoxicity assessment in the Gulf of Follonica, Tuscany (Northern Tyrrhenian Sea)

Patrizia Guidi, Simonetta Corsolini, Margherita Bernardeschi, Lucia Rocco, Marco Nigro^*, Davide Baroni, Filomena Mottola, Vittoria Scarcelli, Marianna Santonastaso, Alessandra Falleni, Camilla Della Torre, Ilaria Corsi, Karla Pozo, Giada Frenzilli

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The Gulf of Follonica (Italy) is impacted by the chemical pollution from ancient mining activity and present industrial processes. This study was aimed to determine the bioavailability of dioxin-like compounds (DLCs) in coastal marine environment and to assess the genotoxic potential of waste waters entering the sea from an industrial canal. Moderately high levels of DCLs compounds (∑ PCDDs + PCDFs 2.18–29.00 pg/g dry wt) were detected in Mytilus galloprovincialis transplanted near the waste waters canal and their corresponding Toxic Equivalents (TEQs) calculated. In situ exposed mussels did not show any genotoxic effect (by Comet and Micronucleus assay). Otherwise, laboratory exposure to canal waters exhibited a reduced genomic template stability (by RAPD-PCR assay) but not DNA or chromosomal damage. Our data reveal the need to focus on the levels and distribution of DLCs in edible species from the study area considering their potential transfer to humans through the consumption of sea food.

Original language	English
Pages (from-to)	467-472
Number of pages	6
Journal	Marine Pollution Bulletin
Volume	126
DOIs	https://doi.org/10.1016/j.marpolbul.2017.11.062
State	Published - 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

ASJC Scopus subject areas

Oceanography
Aquatic Science
Pollution

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.marpolbul.2017.11.062

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Guidi, P., Corsolini, S., Bernardeschi, M., Rocco, L., Nigro, M., Baroni, D., Mottola, F., Scarcelli, V., Santonastaso, M., Falleni, A., Della Torre, C., Corsi, I., Pozo, K., & Frenzilli, G. (2018). Dioxin-like compounds bioavailability and genotoxicity assessment in the Gulf of Follonica, Tuscany (Northern Tyrrhenian Sea). Marine Pollution Bulletin, 126, 467-472. https://doi.org/10.1016/j.marpolbul.2017.11.062

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title = "Dioxin-like compounds bioavailability and genotoxicity assessment in the Gulf of Follonica, Tuscany (Northern Tyrrhenian Sea)",

abstract = "The Gulf of Follonica (Italy) is impacted by the chemical pollution from ancient mining activity and present industrial processes. This study was aimed to determine the bioavailability of dioxin-like compounds (DLCs) in coastal marine environment and to assess the genotoxic potential of waste waters entering the sea from an industrial canal. Moderately high levels of DCLs compounds (∑ PCDDs + PCDFs 2.18–29.00 pg/g dry wt) were detected in Mytilus galloprovincialis transplanted near the waste waters canal and their corresponding Toxic Equivalents (TEQs) calculated. In situ exposed mussels did not show any genotoxic effect (by Comet and Micronucleus assay). Otherwise, laboratory exposure to canal waters exhibited a reduced genomic template stability (by RAPD-PCR assay) but not DNA or chromosomal damage. Our data reveal the need to focus on the levels and distribution of DLCs in edible species from the study area considering their potential transfer to humans through the consumption of sea food.",

keywords = "Cytome-Micronucleus assay, DNA damage, PCBs, PCDDs/DFs, RAPD-PCR, TEQs",

author = "Patrizia Guidi and Simonetta Corsolini and Margherita Bernardeschi and Lucia Rocco and Marco Nigro and Davide Baroni and Filomena Mottola and Vittoria Scarcelli and Marianna Santonastaso and Alessandra Falleni and {Della Torre}, Camilla and Ilaria Corsi and Karla Pozo and Giada Frenzilli",

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year = "2018",

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doi = "10.1016/j.marpolbul.2017.11.062",

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Guidi, P, Corsolini, S, Bernardeschi, M, Rocco, L, Nigro, M, Baroni, D, Mottola, F, Scarcelli, V, Santonastaso, M, Falleni, A, Della Torre, C, Corsi, I, Pozo, K & Frenzilli, G 2018, 'Dioxin-like compounds bioavailability and genotoxicity assessment in the Gulf of Follonica, Tuscany (Northern Tyrrhenian Sea)', Marine Pollution Bulletin, vol. 126, pp. 467-472. https://doi.org/10.1016/j.marpolbul.2017.11.062

TY - JOUR

T1 - Dioxin-like compounds bioavailability and genotoxicity assessment in the Gulf of Follonica, Tuscany (Northern Tyrrhenian Sea)

AU - Guidi, Patrizia

AU - Corsolini, Simonetta

AU - Bernardeschi, Margherita

AU - Rocco, Lucia

AU - Nigro, Marco

AU - Baroni, Davide

AU - Mottola, Filomena

AU - Scarcelli, Vittoria

AU - Santonastaso, Marianna

AU - Falleni, Alessandra

AU - Della Torre, Camilla

AU - Corsi, Ilaria

AU - Pozo, Karla

AU - Frenzilli, Giada

PY - 2018/1

Y1 - 2018/1

N2 - The Gulf of Follonica (Italy) is impacted by the chemical pollution from ancient mining activity and present industrial processes. This study was aimed to determine the bioavailability of dioxin-like compounds (DLCs) in coastal marine environment and to assess the genotoxic potential of waste waters entering the sea from an industrial canal. Moderately high levels of DCLs compounds (∑ PCDDs + PCDFs 2.18–29.00 pg/g dry wt) were detected in Mytilus galloprovincialis transplanted near the waste waters canal and their corresponding Toxic Equivalents (TEQs) calculated. In situ exposed mussels did not show any genotoxic effect (by Comet and Micronucleus assay). Otherwise, laboratory exposure to canal waters exhibited a reduced genomic template stability (by RAPD-PCR assay) but not DNA or chromosomal damage. Our data reveal the need to focus on the levels and distribution of DLCs in edible species from the study area considering their potential transfer to humans through the consumption of sea food.

AB - The Gulf of Follonica (Italy) is impacted by the chemical pollution from ancient mining activity and present industrial processes. This study was aimed to determine the bioavailability of dioxin-like compounds (DLCs) in coastal marine environment and to assess the genotoxic potential of waste waters entering the sea from an industrial canal. Moderately high levels of DCLs compounds (∑ PCDDs + PCDFs 2.18–29.00 pg/g dry wt) were detected in Mytilus galloprovincialis transplanted near the waste waters canal and their corresponding Toxic Equivalents (TEQs) calculated. In situ exposed mussels did not show any genotoxic effect (by Comet and Micronucleus assay). Otherwise, laboratory exposure to canal waters exhibited a reduced genomic template stability (by RAPD-PCR assay) but not DNA or chromosomal damage. Our data reveal the need to focus on the levels and distribution of DLCs in edible species from the study area considering their potential transfer to humans through the consumption of sea food.

KW - Cytome-Micronucleus assay

KW - DNA damage

KW - PCBs

KW - PCDDs/DFs

KW - RAPD-PCR

KW - TEQs

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DO - 10.1016/j.marpolbul.2017.11.062

M3 - Article

C2 - 29421127

AN - SCOPUS:85037367459

SN - 0025-326X

VL - 126

SP - 467

EP - 472

JO - Marine Pollution Bulletin

JF - Marine Pollution Bulletin

ER -

Dioxin-like compounds bioavailability and genotoxicity assessment in the Gulf of Follonica, Tuscany (Northern Tyrrhenian Sea)

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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