Dexamethasone, aldosterone and kallikrein release by isolated rat kidney

C. P. Vio; J. S. Roblero; H. R. Croxatto

doi:10.1042/cs0610241

Dexamethasone, aldosterone and kallikrein release by isolated rat kidney

C. P. Vio, J. S. Roblero, H. R. Croxatto

Universidad Austral de Chile

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The effect of D-aldosterone and dexamethasone on kallikrein release was studied in the isolated rat kidney perfused with modified Krebs-Henseleit buffer. Animals received D-aldosterone or dexamethasone (10μg/100 g body weight) daily for 3 days. Their isolated kidneys were then perfused with the same steroids at rates at 2.0-2.5 μg/min for 30 min. Dexamethasone increased kallikrein release signficantly (P<0.001) both in urine and in venous outflow. D-Aldosterone had no significant effect on kallikrein release, either in urine or in venous outflow.

Original language	English
Pages (from-to)	241-243
Number of pages	3
Journal	Clinical Science
Volume	61
Issue number	2
DOIs	https://doi.org/10.1042/cs0610241
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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abstract = "The effect of D-aldosterone and dexamethasone on kallikrein release was studied in the isolated rat kidney perfused with modified Krebs-Henseleit buffer. Animals received D-aldosterone or dexamethasone (10μg/100 g body weight) daily for 3 days. Their isolated kidneys were then perfused with the same steroids at rates at 2.0-2.5 μg/min for 30 min. Dexamethasone increased kallikrein release signficantly (P<0.001) both in urine and in venous outflow. D-Aldosterone had no significant effect on kallikrein release, either in urine or in venous outflow.",

author = "Vio, {C. P.} and Roblero, {J. S.} and Croxatto, {H. R.}",

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AB - The effect of D-aldosterone and dexamethasone on kallikrein release was studied in the isolated rat kidney perfused with modified Krebs-Henseleit buffer. Animals received D-aldosterone or dexamethasone (10μg/100 g body weight) daily for 3 days. Their isolated kidneys were then perfused with the same steroids at rates at 2.0-2.5 μg/min for 30 min. Dexamethasone increased kallikrein release signficantly (P<0.001) both in urine and in venous outflow. D-Aldosterone had no significant effect on kallikrein release, either in urine or in venous outflow.

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Dexamethasone, aldosterone and kallikrein release by isolated rat kidney

Abstract

ASJC Scopus subject areas

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