TY - JOUR
T1 - Development of microbial resistant Carbopol nanocomposite hydrogels via a green process
AU - Varaprasad, Kokkarachedu
AU - Siva Mohan Reddy, G.
AU - Jayaramudu, J.
AU - Sadiku, Rotimi
AU - Ramam, Koduri
AU - Ray, S. Sinha
PY - 2014/2
Y1 - 2014/2
N2 - The present scientific research resulted in the development of novel microbial resistant inorganic nanocomposite hydrogels, which can be used as antibacterial agents. They are promising candidates for advanced antimicrobial applications in the field of biomedical science. Novel inorganic nanocomposite hydrogels were developed from Carbopol® 980 NF and acrylamide. Dual-metallic (Ag0-Au0) nanoparticles were prepared (via a green process) by the nucleation of silver and gold salts with mint leaf extract to form a hydrogel network. The Carbopol nanocomposite hydrogels contain (Ag 0-Au0) nanoparticles ∼5 ± 3 nm in size, which was confirmed by transmission electron microscopy. The developed hydrogels were characterized using Fourier transform infrared (FTIR) spectroscopy, thermo-gravimetric analysis (TGA), scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS) and transmission electron microscopy (TEM). The pure and inorganic nanocomposite hydrogels developed were tested against Bacillus and E. coli, for their antibacterial properties. The results indicate that the inorganic nanocomposites show significantly greater antimicrobial activity than the pure hydrogels. Therefore, novel microbial resistant Carbopol nanocomposite hydrogels can be used as potential candidates for antibacterial applications.
AB - The present scientific research resulted in the development of novel microbial resistant inorganic nanocomposite hydrogels, which can be used as antibacterial agents. They are promising candidates for advanced antimicrobial applications in the field of biomedical science. Novel inorganic nanocomposite hydrogels were developed from Carbopol® 980 NF and acrylamide. Dual-metallic (Ag0-Au0) nanoparticles were prepared (via a green process) by the nucleation of silver and gold salts with mint leaf extract to form a hydrogel network. The Carbopol nanocomposite hydrogels contain (Ag 0-Au0) nanoparticles ∼5 ± 3 nm in size, which was confirmed by transmission electron microscopy. The developed hydrogels were characterized using Fourier transform infrared (FTIR) spectroscopy, thermo-gravimetric analysis (TGA), scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS) and transmission electron microscopy (TEM). The pure and inorganic nanocomposite hydrogels developed were tested against Bacillus and E. coli, for their antibacterial properties. The results indicate that the inorganic nanocomposites show significantly greater antimicrobial activity than the pure hydrogels. Therefore, novel microbial resistant Carbopol nanocomposite hydrogels can be used as potential candidates for antibacterial applications.
UR - http://www.scopus.com/inward/record.url?scp=84891436501&partnerID=8YFLogxK
U2 - 10.1039/c3bm60185d
DO - 10.1039/c3bm60185d
M3 - Article
AN - SCOPUS:84891436501
SN - 2047-4830
VL - 2
SP - 257
EP - 263
JO - Biomaterials Science
JF - Biomaterials Science
IS - 2
ER -