TY - JOUR
T1 - Brain immunity response of fish Eleginops maclovinus to infection with Francisella noatunensis
T2 - The brain´s immunity response
AU - Quilapi, Ana María
AU - Vargas-Lagos, Carolina
AU - Martínez, Danixa
AU - Muñoz, Jose Luis
AU - Spies, Johana
AU - Esperguel, Ivan
AU - Tapia, Jaime
AU - Oyarzún-Salazar, Ricardo
AU - Vargas-Chacoff, Luis
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/1
Y1 - 2022/1
N2 - The brain's immune system is selective and hermetic in most species, including fish, favoring immune responses mediated by soluble immunomodulatory factors such as serotonin and the availability of nutrients against infectious processes. Francisella noatunensis coexist with fish such as Eleginops maclovinus, which raises questions about the susceptibility and immune response of the brain of E. maclovinus against Francisella. In this study, we inoculated fish with different doses of Francisella and took samples for 28 days. We detected bacteria in the brain of fish injected with a high concentration of Francisella at all time points. qPCR analysis of immune genes indicated a response mainly in the medium-dose and early expression of genes involved in iron metabolism. Finally, brain serotonin levels were higher than in uninfected fish in all conditions, suggesting possible immunomodulatory participation in an infectious process.
AB - The brain's immune system is selective and hermetic in most species, including fish, favoring immune responses mediated by soluble immunomodulatory factors such as serotonin and the availability of nutrients against infectious processes. Francisella noatunensis coexist with fish such as Eleginops maclovinus, which raises questions about the susceptibility and immune response of the brain of E. maclovinus against Francisella. In this study, we inoculated fish with different doses of Francisella and took samples for 28 days. We detected bacteria in the brain of fish injected with a high concentration of Francisella at all time points. qPCR analysis of immune genes indicated a response mainly in the medium-dose and early expression of genes involved in iron metabolism. Finally, brain serotonin levels were higher than in uninfected fish in all conditions, suggesting possible immunomodulatory participation in an infectious process.
KW - Brain
KW - Eleginops maclovinus
KW - Francisella noatunensis
KW - Immune response
KW - Iron
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=85121976359&partnerID=8YFLogxK
U2 - 10.1016/j.fsi.2021.11.026
DO - 10.1016/j.fsi.2021.11.026
M3 - Article
C2 - 34808359
AN - SCOPUS:85121976359
SN - 1050-4648
VL - 120
SP - 695
EP - 705
JO - Fish and Shellfish Immunology
JF - Fish and Shellfish Immunology
ER -