Biodegradable Microspheres for Controlled Release of an Antibiotic Ciprofloxacin

S. Ravindra; K. Varaprasad; Narayana Reddy; K. Vimala; K. Mohana Raju

doi:10.1007/s10924-011-0290-8

Biodegradable Microspheres for Controlled Release of an Antibiotic Ciprofloxacin

S. Ravindra, K. Varaprasad, Narayana Reddy, K. Vimala, K. Mohana Raju

Sri Krishnadevaraya University India

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Ciprofloxacin (CF) loaded biodegradable microspheres of Poly(lactide-co-caprolactone)-PF127 (a poloxamer block copolymer of Ethylene Oxide/Propylene Oxide) were prepared by using solvent evaporation technique. The microspheres were characterized by differential scanning calorimetry (DSC) and X-ray diffractometry (X-RD) technique to confirm the polymorphism of ciproflaxacin (CF) drug. The X-RD and DSC techniques indicated molecular level dispersion of CF in the microspheres. Scanning electron micrographic images (SEM) of the microspheres indicated smooth surfaces of the spherical microspheres. Cumulative release characteristics of the matrices for CF, the antibiotic drug, were investigated in pH 7. 4 media. It was possible to release CF in controlled manner up to 72 h. The developed ciprofloxacin loaded Poly(lactide-co-caprolactone)-PF127 microspheres were evaluated for preliminary antibacterial applications.

Original language	English
Pages (from-to)	413-418
Number of pages	6
Journal	Journal of Polymers and the Environment
Volume	19
Issue number	2
DOIs	https://doi.org/10.1007/s10924-011-0290-8
State	Published - 2011
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments The authors (KMR & SR) thanks the University Grants Commission (UGC-SAP), Government of India, New Delhi for the partial financial support.

ASJC Scopus subject areas

Environmental Engineering
Polymers and Plastics
Materials Chemistry

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10.1007/s10924-011-0290-8

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title = "Biodegradable Microspheres for Controlled Release of an Antibiotic Ciprofloxacin",

abstract = "Ciprofloxacin (CF) loaded biodegradable microspheres of Poly(lactide-co-caprolactone)-PF127 (a poloxamer block copolymer of Ethylene Oxide/Propylene Oxide) were prepared by using solvent evaporation technique. The microspheres were characterized by differential scanning calorimetry (DSC) and X-ray diffractometry (X-RD) technique to confirm the polymorphism of ciproflaxacin (CF) drug. The X-RD and DSC techniques indicated molecular level dispersion of CF in the microspheres. Scanning electron micrographic images (SEM) of the microspheres indicated smooth surfaces of the spherical microspheres. Cumulative release characteristics of the matrices for CF, the antibiotic drug, were investigated in pH 7. 4 media. It was possible to release CF in controlled manner up to 72 h. The developed ciprofloxacin loaded Poly(lactide-co-caprolactone)-PF127 microspheres were evaluated for preliminary antibacterial applications.",

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author = "S. Ravindra and K. Varaprasad and Narayana Reddy and K. Vimala and Raju, {K. Mohana}",

note = "Funding Information: Acknowledgments The authors (KMR & SR) thanks the University Grants Commission (UGC-SAP), Government of India, New Delhi for the partial financial support.",

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doi = "10.1007/s10924-011-0290-8",

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AU - Ravindra, S.

AU - Varaprasad, K.

AU - Reddy, Narayana

AU - Vimala, K.

AU - Raju, K. Mohana

N1 - Funding Information: Acknowledgments The authors (KMR & SR) thanks the University Grants Commission (UGC-SAP), Government of India, New Delhi for the partial financial support.

PY - 2011/6

Y1 - 2011/6

N2 - Ciprofloxacin (CF) loaded biodegradable microspheres of Poly(lactide-co-caprolactone)-PF127 (a poloxamer block copolymer of Ethylene Oxide/Propylene Oxide) were prepared by using solvent evaporation technique. The microspheres were characterized by differential scanning calorimetry (DSC) and X-ray diffractometry (X-RD) technique to confirm the polymorphism of ciproflaxacin (CF) drug. The X-RD and DSC techniques indicated molecular level dispersion of CF in the microspheres. Scanning electron micrographic images (SEM) of the microspheres indicated smooth surfaces of the spherical microspheres. Cumulative release characteristics of the matrices for CF, the antibiotic drug, were investigated in pH 7. 4 media. It was possible to release CF in controlled manner up to 72 h. The developed ciprofloxacin loaded Poly(lactide-co-caprolactone)-PF127 microspheres were evaluated for preliminary antibacterial applications.

AB - Ciprofloxacin (CF) loaded biodegradable microspheres of Poly(lactide-co-caprolactone)-PF127 (a poloxamer block copolymer of Ethylene Oxide/Propylene Oxide) were prepared by using solvent evaporation technique. The microspheres were characterized by differential scanning calorimetry (DSC) and X-ray diffractometry (X-RD) technique to confirm the polymorphism of ciproflaxacin (CF) drug. The X-RD and DSC techniques indicated molecular level dispersion of CF in the microspheres. Scanning electron micrographic images (SEM) of the microspheres indicated smooth surfaces of the spherical microspheres. Cumulative release characteristics of the matrices for CF, the antibiotic drug, were investigated in pH 7. 4 media. It was possible to release CF in controlled manner up to 72 h. The developed ciprofloxacin loaded Poly(lactide-co-caprolactone)-PF127 microspheres were evaluated for preliminary antibacterial applications.

KW - Biodegradable microspheres

KW - Ciprofloxacin

KW - Controlled release

KW - Solvent evaporation

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JF - Journal of Polymers and the Environment

IS - 2

ER -

Biodegradable Microspheres for Controlled Release of an Antibiotic Ciprofloxacin

Abstract

Bibliographical note

ASJC Scopus subject areas

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