TY - JOUR
T1 - Biodegradable Chitosan Hydrogels for In Vitro Drug Release Studies of 5-Flurouracil an Anticancer Drug
AU - Varaprasad, Kokkarachedu
AU - Vimala, K.
AU - Ravindra, Sakey
AU - Narayana Reddy, N.
AU - Siva Mohana Reddy, G.
AU - Mohana Raju, K.
PY - 2012/6
Y1 - 2012/6
N2 - Novel semi-interpenetrating network (semi-IPN) hydrogels based on biodegradable chitosan and poly(N-isopropylacrylamide-co-2-acrylamido-2-methyl-1-propanesulfonic acid) were prepared by free radical addition polymerization. Fourier transform infrared spectra and scanning electron microscopy were used to characterize the semi-IPN hydrogels and the results showed that chitosan and poly(N-isopropylacrylamide-co-2-acrylamide-2-methyl-1-propanesulfonic acid) semi-IPN hydrogels were coupled by the interaction of the functional groups present in NIPAAm, CS and AMPS units. The PNIPAAm and P(NIPAAm-AMPS)/CS hydrogels have lower critical solution temperature and the same was confirmed with the help of differential scanning calorimetry as well as with the temperature dependent swelling curves. The model anti cancer drug, 5-fluorouracil (5-FU) was loaded into the semi-IPN hydrogels, at ambient temperature. The 5-FU loading capacity and release behaviour were investigated with these hydrogels acting as carriers for controlled release. The released 5-FU concentration was calculated with the help of UV spectrophotometer at 266. 5 nm.
AB - Novel semi-interpenetrating network (semi-IPN) hydrogels based on biodegradable chitosan and poly(N-isopropylacrylamide-co-2-acrylamido-2-methyl-1-propanesulfonic acid) were prepared by free radical addition polymerization. Fourier transform infrared spectra and scanning electron microscopy were used to characterize the semi-IPN hydrogels and the results showed that chitosan and poly(N-isopropylacrylamide-co-2-acrylamide-2-methyl-1-propanesulfonic acid) semi-IPN hydrogels were coupled by the interaction of the functional groups present in NIPAAm, CS and AMPS units. The PNIPAAm and P(NIPAAm-AMPS)/CS hydrogels have lower critical solution temperature and the same was confirmed with the help of differential scanning calorimetry as well as with the temperature dependent swelling curves. The model anti cancer drug, 5-fluorouracil (5-FU) was loaded into the semi-IPN hydrogels, at ambient temperature. The 5-FU loading capacity and release behaviour were investigated with these hydrogels acting as carriers for controlled release. The released 5-FU concentration was calculated with the help of UV spectrophotometer at 266. 5 nm.
KW - 5-Fluorouracil and hydrogels
KW - Biodegradable
KW - Lower critical solution temperature
KW - Semi-interpenetrating network
UR - http://www.scopus.com/inward/record.url?scp=84861182849&partnerID=8YFLogxK
U2 - 10.1007/s10924-012-0412-y
DO - 10.1007/s10924-012-0412-y
M3 - Article
AN - SCOPUS:84861182849
SN - 1566-2543
VL - 20
SP - 573
EP - 582
JO - Journal of Polymers and the Environment
JF - Journal of Polymers and the Environment
IS - 2
ER -
