Basic pathways and targets for anti-aging intervention

Mercedes Cano; Yiu To Yeung; Mario F. Muñoz; Antonio Ayala; Angélica Guerrero-Castilla; Sandro Argüelles

doi:10.1016/B978-0-12-823679-6.00003-5

Basic pathways and targets for anti-aging intervention

Mercedes Cano, Yiu To Yeung, Mario F. Muñoz, Antonio Ayala, Angélica Guerrero-Castilla, Sandro Argüelles

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Aging is a natural, highly complex, and heterogenous process involving progressive loss of physiological functioning and a deficiency in cellular homeostasis. Aging is the highest risk factor for developing chronic pathologies. Hallmarks of aging include downregulation of metabolic anti-aging or prolongevity pathways—AMP-activated protein kinase and silencing information regulator 2 related enzyme 1—and upregulation of the proaging mammalian target of rapamycin and insulin/IGF-1 pathways; loss of mitochondrial function, proteostasis, and stem cell regenerative capacity; persistent and uncontrolled production of senescence-associated secretory phenotype reactive oxygen species and proinflammatory molecules, telomere erosion, chromatin and epigenetic alterations, and lost RNA quality control. This chapter summarizes how the aforementioned molecular and cellular DNA, RNA, and protein mechanisms contribute to aging.

Original language	English
Title of host publication	Anti-Aging Pharmacology
Publisher	Elsevier
Pages	13-40
Number of pages	28
ISBN (Electronic)	9780128236796
ISBN (Print)	9780128236802
DOIs	https://doi.org/10.1016/B978-0-12-823679-6.00003-5
State	Published - 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc. All rights reserved.

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-823679-6.00003-5

Cite this

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AU - Yeung, Yiu To

AU - Muñoz, Mario F.

AU - Ayala, Antonio

AU - Guerrero-Castilla, Angélica

AU - Argüelles, Sandro

PY - 2023/1/19

Y1 - 2023/1/19

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KW - Aging

KW - Anti-aging pathway

KW - Mitochondrial dysfunction

KW - Proaging pathway

KW - Proteostasis

KW - RNA quality

KW - Senescence

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BT - Anti-Aging Pharmacology

PB - Elsevier

ER -

Basic pathways and targets for anti-aging intervention

Abstract

Bibliographical note

ASJC Scopus subject areas

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