Anatomical relationship between kallikrein- containing tubules and the juxtaglomerular apparatus in the human kidney

Carlos P. Vio; Carlos D. Figueroa; Italo Caorsi

doi:10.1093/ajh/1.3.269

Anatomical relationship between kallikrein- containing tubules and the juxtaglomerular apparatus in the human kidney

Carlos P. Vio^*, Carlos D. Figueroa, Italo Caorsi

^*Corresponding author for this work

Pontificia Universidad Católica de Chile

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Current evidence suggests a functional and biochemical link between the renin and the kallikrein Systems. The purpose of this work was to study the localization of kallikrein along the human nephron to elucidate whethei there exists an anatomical base for such interrelation.Serial sections of human kidney tissue were stained by immunocytochemical methods with antisera against kallikrein. Kallikrein immunostaining was observed ex- clusively in segments of the distal nephron lying in the cortical labyrinths and forming arcades in its distal portion. Consistently the tubules containing kallikrein established a close anatomical relationship with the afferent arteriole of the juxtaglomerular apparatus providing an anatomical base for an interaction between the renin and kallikrein Systems in the human kidney.

Original language	English
Pages (from-to)	269-271
Number of pages	3
Journal	American Journal of Hypertension
Volume	1
Issue number	3
DOIs	https://doi.org/10.1093/ajh/1.3.269
State	Published - 1988
Externally published	Yes

Bibliographical note

Funding Information:
Supported by Grants FONDECYT 2047/87, DIUC 202/86, and DID-UACH S 85-38.

ASJC Scopus subject areas

Internal Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ajh/1.3.269

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title = "Anatomical relationship between kallikrein- containing tubules and the juxtaglomerular apparatus in the human kidney",

abstract = "Current evidence suggests a functional and biochemical link between the renin and the kallikrein Systems. The purpose of this work was to study the localization of kallikrein along the human nephron to elucidate whethei there exists an anatomical base for such interrelation.Serial sections of human kidney tissue were stained by immunocytochemical methods with antisera against kallikrein. Kallikrein immunostaining was observed ex- clusively in segments of the distal nephron lying in the cortical labyrinths and forming arcades in its distal portion. Consistently the tubules containing kallikrein established a close anatomical relationship with the afferent arteriole of the juxtaglomerular apparatus providing an anatomical base for an interaction between the renin and kallikrein Systems in the human kidney.",

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author = "Vio, {Carlos P.} and Figueroa, {Carlos D.} and Italo Caorsi",

note = "Funding Information: Supported by Grants FONDECYT 2047/87, DIUC 202/86, and DID-UACH S 85-38.",

year = "1988",

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doi = "10.1093/ajh/1.3.269",

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AU - Vio, Carlos P.

AU - Figueroa, Carlos D.

AU - Caorsi, Italo

N1 - Funding Information: Supported by Grants FONDECYT 2047/87, DIUC 202/86, and DID-UACH S 85-38.

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N2 - Current evidence suggests a functional and biochemical link between the renin and the kallikrein Systems. The purpose of this work was to study the localization of kallikrein along the human nephron to elucidate whethei there exists an anatomical base for such interrelation.Serial sections of human kidney tissue were stained by immunocytochemical methods with antisera against kallikrein. Kallikrein immunostaining was observed ex- clusively in segments of the distal nephron lying in the cortical labyrinths and forming arcades in its distal portion. Consistently the tubules containing kallikrein established a close anatomical relationship with the afferent arteriole of the juxtaglomerular apparatus providing an anatomical base for an interaction between the renin and kallikrein Systems in the human kidney.

AB - Current evidence suggests a functional and biochemical link between the renin and the kallikrein Systems. The purpose of this work was to study the localization of kallikrein along the human nephron to elucidate whethei there exists an anatomical base for such interrelation.Serial sections of human kidney tissue were stained by immunocytochemical methods with antisera against kallikrein. Kallikrein immunostaining was observed ex- clusively in segments of the distal nephron lying in the cortical labyrinths and forming arcades in its distal portion. Consistently the tubules containing kallikrein established a close anatomical relationship with the afferent arteriole of the juxtaglomerular apparatus providing an anatomical base for an interaction between the renin and kallikrein Systems in the human kidney.

KW - Human kidney

KW - Juxtaglomerular apparatus

KW - Rénal kallikrein

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Anatomical relationship between kallikrein- containing tubules and the juxtaglomerular apparatus in the human kidney

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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