TY - JOUR
T1 - Advances in the fabrication of antimicrobial hydrogels for biomedical applications
AU - González-Henríquez, Carmen M.
AU - Sarabia-Vallejos, Mauricio A.
AU - Rodriguez-Hernandez, Juan
N1 - Publisher Copyright:
© 2017 by the authors.
PY - 2017
Y1 - 2017
N2 - This review describes, in an organized manner, the recent developments in the elaboration of hydrogels that possess antimicrobial activity. The fabrication of antibacterial hydrogels for biomedical applications that permits cell adhesion and proliferation still remains as an interesting challenge, in particular for tissue engineering applications. In this context, a large number of studies has been carried out in the design of hydrogels that serve as support for antimicrobial agents (nanoparticles, antibiotics, etc.). Another interesting approach is to use polymers with inherent antimicrobial activity provided by functional groups contained in their structures, such as quaternary ammonium salt or hydrogels fabricated from antimicrobial peptides (AMPs) or natural polymers, such as chitosan. A summary of the different alternatives employed for this purpose is described in this review, considering their advantages and disadvantages. Finally, more recent methodologies that lead to more sophisticated hydrogels that are able to react to external stimuli are equally depicted in this review.
AB - This review describes, in an organized manner, the recent developments in the elaboration of hydrogels that possess antimicrobial activity. The fabrication of antibacterial hydrogels for biomedical applications that permits cell adhesion and proliferation still remains as an interesting challenge, in particular for tissue engineering applications. In this context, a large number of studies has been carried out in the design of hydrogels that serve as support for antimicrobial agents (nanoparticles, antibiotics, etc.). Another interesting approach is to use polymers with inherent antimicrobial activity provided by functional groups contained in their structures, such as quaternary ammonium salt or hydrogels fabricated from antimicrobial peptides (AMPs) or natural polymers, such as chitosan. A summary of the different alternatives employed for this purpose is described in this review, considering their advantages and disadvantages. Finally, more recent methodologies that lead to more sophisticated hydrogels that are able to react to external stimuli are equally depicted in this review.
KW - Antimicrobial activity
KW - Antimicrobial agents
KW - Chitosan
KW - Hydrogels
KW - Silver nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85015047110&partnerID=8YFLogxK
U2 - 10.3390/ma10030232
DO - 10.3390/ma10030232
M3 - Review article
AN - SCOPUS:85015047110
SN - 1996-1944
VL - 10
JO - Materials
JF - Materials
IS - 3
M1 - 232
ER -