TY - JOUR
T1 - A Systematic Review and Meta-Analysis on the Prevalence of Variants in the Pancreaticobiliary Duct Junction and Its Association with Cancer
AU - Riveros Valdés, Andrés Sebastián
AU - Fuenzalida, Juan José Valenzuela
AU - Beas-Gambi, Antonia
AU - Leiva, Josefa Matta
AU - Martínez-Hernández, Daniela
AU - Milos, Daniel
AU - Orellana-Donoso, Mathias
AU - Suazo Santibáñez, Alejandra
AU - Bruna Mejias, Alejandro
AU - Becerra-Farfan, Alvaro
AU - Sanchis-Gimeno, Juan A.
AU - Gutiérrez-Espinoza, Héctor
AU - Bastidas-Caldes, Carlos
N1 - Publisher Copyright:
© 2025 by the authors.
PY - 2025/5
Y1 - 2025/5
N2 - Background/Objectives: The objective of this study was to describe the anatomical variants of the pancreaticobiliary junction and how its position or structural change could be associated with hepatic, duodenal, and pancreatic clinical complications. Methods: We searched MEDLINE, Scopus, Web of Science (WOS), Google Scholar, CINAHL, and EMBASE databases from their inception up to September 2024. Results: Two authors independently performed the search, study selection, data extraction, and assessed the methodological quality with an assurance tool for anatomical studies (AQUA). Finally, the pooled prevalence was estimated using a random effects model. A total of 59 studies with a total of 22,752 participants were included in this review. The overall prevalence of the anomalous pancreaticobiliary junction (APBJ) variant was 12% (95% CI = 6% to 18%). The prevalence of cancer associated with variants of APBJ was 29% (95% CI = 23% to 34%). Conclusions: In the present anatomical systematic review and meta-analysis, we found that a longer common channel correlated with a higher prevalence of bile duct or gallbladder malignancy, due to the backward flow of bile which occurs as a result of the position and distance of the bile ducts, as well as pancreatic failing. Hence, APBJs are of great interest for gastroduodenal surgeons.
AB - Background/Objectives: The objective of this study was to describe the anatomical variants of the pancreaticobiliary junction and how its position or structural change could be associated with hepatic, duodenal, and pancreatic clinical complications. Methods: We searched MEDLINE, Scopus, Web of Science (WOS), Google Scholar, CINAHL, and EMBASE databases from their inception up to September 2024. Results: Two authors independently performed the search, study selection, data extraction, and assessed the methodological quality with an assurance tool for anatomical studies (AQUA). Finally, the pooled prevalence was estimated using a random effects model. A total of 59 studies with a total of 22,752 participants were included in this review. The overall prevalence of the anomalous pancreaticobiliary junction (APBJ) variant was 12% (95% CI = 6% to 18%). The prevalence of cancer associated with variants of APBJ was 29% (95% CI = 23% to 34%). Conclusions: In the present anatomical systematic review and meta-analysis, we found that a longer common channel correlated with a higher prevalence of bile duct or gallbladder malignancy, due to the backward flow of bile which occurs as a result of the position and distance of the bile ducts, as well as pancreatic failing. Hence, APBJs are of great interest for gastroduodenal surgeons.
KW - pancreaticobiliary junction
KW - pancreaticobiliary maljunction
KW - cancer
KW - pancreaticobiliary junction cancer
KW - cancer
KW - pancreaticobiliary junction (PBJ)
KW - pancreaticobiliary junction cancer
KW - pancreaticobiliary maljunction
UR - http://www.scopus.com/inward/record.url?scp=105006772737&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/9f900b29-a7f0-310e-a57c-48cc3a3fa0fc/
U2 - 10.3390/biomedicines13051039
DO - 10.3390/biomedicines13051039
M3 - Review article
AN - SCOPUS:105006772737
SN - 2227-9059
VL - 13
SP - 1039
EP - 1060
JO - Biomedicines
JF - Biomedicines
IS - 5
M1 - 1039
ER -
