5-Fluorouracil encapsulated magnetic nanohydrogels for drug-delivery applications

Tippabattini Jayaramudu; Gownolla Malegowd Raghavendra; Kokkarachedu Varaprasad; Konduru Mohana Raju; Emmanuel Rotimi Sadiku; Jaehwan Kim

doi:10.1002/app.43921

5-Fluorouracil encapsulated magnetic nanohydrogels for drug-delivery applications

Tippabattini Jayaramudu^*, Gownolla Malegowd Raghavendra, Kokkarachedu Varaprasad, Konduru Mohana Raju, Emmanuel Rotimi Sadiku, Jaehwan Kim

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

For the first time, green-tea (GT)-based magnetic nanohydrogels were developed for drug-delivery purposes. The hydrogel matrices were fabricated via the in situ polymerization of acrylamide with GT molecules. Magnetic nanoparticles were synthesized by the reduction of the 1:2 molar ratio mixture of ferrous sulfate heptahydrate and ferric chloride hexahydrate with an ammonia solution. A chemotherapeutic drug, 5-fluorouracil, was chosen as a model drug, and its releasing profiles in the presence and absence of the external magnetic field were evaluated at a pH of 7.4. We observed that in the presence of the applied magnetic field, these magnetic nanohydrogels released 2.86% more drug than in the absence of a magnetic field. The magnetic nanohydrogels were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy.

Original language	English
Article number	APP43921
Journal	Journal of Applied Polymer Science
Volume	133
Issue number	37
DOIs	https://doi.org/10.1002/app.43921
State	Published - 2016
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (contract grant number NRF-2015R1A3A2066301) and the author Kokkarachedu Varaprasad wishes to acknowledge the Programa de Atracción e Inserciun de Capital Humano Avanzado (PAI) Proyecto No. 781302011, CONICYT, Chile and the CIPA, CONICYT Regional PRFC0002.

Publisher Copyright:
© 2016 Wiley Periodicals, Inc.

ASJC Scopus subject areas

General Chemistry
Surfaces, Coatings and Films
Polymers and Plastics
Materials Chemistry

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title = "5-Fluorouracil encapsulated magnetic nanohydrogels for drug-delivery applications",

abstract = "For the first time, green-tea (GT)-based magnetic nanohydrogels were developed for drug-delivery purposes. The hydrogel matrices were fabricated via the in situ polymerization of acrylamide with GT molecules. Magnetic nanoparticles were synthesized by the reduction of the 1:2 molar ratio mixture of ferrous sulfate heptahydrate and ferric chloride hexahydrate with an ammonia solution. A chemotherapeutic drug, 5-fluorouracil, was chosen as a model drug, and its releasing profiles in the presence and absence of the external magnetic field were evaluated at a pH of 7.4. We observed that in the presence of the applied magnetic field, these magnetic nanohydrogels released 2.86% more drug than in the absence of a magnetic field. The magnetic nanohydrogels were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy.",

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AU - Raju, Konduru Mohana

AU - Sadiku, Emmanuel Rotimi

AU - Kim, Jaehwan

N1 - Funding Information: This research was supported by the National Research Foundation of Korea (contract grant number NRF-2015R1A3A2066301) and the author Kokkarachedu Varaprasad wishes to acknowledge the Programa de Atracción e Inserciun de Capital Humano Avanzado (PAI) Proyecto No. 781302011, CONICYT, Chile and the CIPA, CONICYT Regional PRFC0002. Publisher Copyright: © 2016 Wiley Periodicals, Inc.

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N2 - For the first time, green-tea (GT)-based magnetic nanohydrogels were developed for drug-delivery purposes. The hydrogel matrices were fabricated via the in situ polymerization of acrylamide with GT molecules. Magnetic nanoparticles were synthesized by the reduction of the 1:2 molar ratio mixture of ferrous sulfate heptahydrate and ferric chloride hexahydrate with an ammonia solution. A chemotherapeutic drug, 5-fluorouracil, was chosen as a model drug, and its releasing profiles in the presence and absence of the external magnetic field were evaluated at a pH of 7.4. We observed that in the presence of the applied magnetic field, these magnetic nanohydrogels released 2.86% more drug than in the absence of a magnetic field. The magnetic nanohydrogels were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy.

AB - For the first time, green-tea (GT)-based magnetic nanohydrogels were developed for drug-delivery purposes. The hydrogel matrices were fabricated via the in situ polymerization of acrylamide with GT molecules. Magnetic nanoparticles were synthesized by the reduction of the 1:2 molar ratio mixture of ferrous sulfate heptahydrate and ferric chloride hexahydrate with an ammonia solution. A chemotherapeutic drug, 5-fluorouracil, was chosen as a model drug, and its releasing profiles in the presence and absence of the external magnetic field were evaluated at a pH of 7.4. We observed that in the presence of the applied magnetic field, these magnetic nanohydrogels released 2.86% more drug than in the absence of a magnetic field. The magnetic nanohydrogels were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy.

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5-Fluorouracil encapsulated magnetic nanohydrogels for drug-delivery applications

Abstract

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