Luis Pablo Cid Soto

2024

Normal vision and development in mice with low functional expression of Kir7.1 in heterozygosis for a blindness-producing mutation inactivating the channel: NA

Cornejo Araneda, I. M., Sepúlveda Valenzuela, F. L., Cid Soto, L. P., Vera, E., Henao, J. C., Tribiños, F. & Burgos, J., 2024, In: American Journal of Physiology - Cell Physiology. 326, 4, p. C1178-C1192

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2023

A new family of glutamate-gated chloride channels in parasitic sea louse Caligus rogercresseyi: A subunit refractory to activation by ivermectin is dominant in heteromeric assemblies

Tribiños, F., Cuevas, P., Cornejo, I., Sepúlveda, F. V. & Pablo Cid, L., 2023, In: PLoS Pathogens. 19, 3 March, p. e1011188 e1011188.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2021

Altered phosphatidylinositol regulation of mutant inwardly rectifying K⁺ Kir7.1 channels associated with inherited retinal degeneration disease

Vera, E., Cornejo, I., Niemeyer, M. I., Sepúlveda, F. V. & Cid, L. P., 2021, In: Journal of Physiology. 599, 2, p. 593-608 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2020

Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action

Catalán, M. A., Julio-Kalajzić, F., Niemeyer, M. I., Cid, L. P. & Sepúlveda, F. V., 2020, In: Cells. 9, 8, 210.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2019

A novel Kir7.1 splice variant expressed in various mouse tissues shares organisational and functional properties with human Leber amaurosis-causing mutations of this K⁺ channel

Vera, E., Cornejo, I., Burgos, J., Niemeyer, M. I., Sepúlveda, F. V. & Cid, L. P., 2019, In: Biochemical and Biophysical Research Communications. 514, 3, p. 574-579 6 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Kir7.1 inwardly rectifying K⁺ channel is expressed in ciliary body non pigment epithelial cells and might contribute to intraocular pressure regulation

Burgos, J., Villanueva, S., Ojeda, M., Cornejo, I., Cid, L. P. & Sepúlveda, F. V., 2019, In: Experimental Eye Research. 186, 107723.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2018

K _2P TASK-2 and KCNQ1–KCNE3 K ⁺ channels are major players contributing to intestinal anion and fluid secretion

Julio-Kalajzić, F., Villanueva, S., Burgos, J., Ojeda, M., Cid, L. P., Jentsch, T. J. & Sepúlveda, F. V., 2018, In: Journal of Physiology. 596, 3, p. 393-407 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the CFTR-F508del mouse

Philp, A. R., Riquelme, T. T., Millar-Büchner, P., González, R., Sepúlveda, F. V., Cid, L. P. & Flores, C. A., 2018, In: Scientific Reports. 8, 9320, p. 1 12 p., 9320.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Reply from L. P. Cid, T. J. Jentsch and F. V. Sepúlveda: intestinal electrolyte and fluid secretion – a model in trouble?

Cid, L. P., Jentsch, T. J. & Sepúlveda, F. V., 2018, In: Journal of Physiology. 596, 12, p. 2465-2466 2 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

1 Scopus citations

Tissue distribution of Kir7.1 inwardly rectifying K⁺ channel probed in a knock-in mouse expressing a haemagglutinin-tagged protein

Cornejo, I., Villanueva, S., Burgos, J., López-Cayuqueo, K. I., Chambrey, R., Julio-Kalajzic, F., Buelvas, N., Niemeyer, M. I., Figueiras-Fierro, D., Brown, P. D., Sepúlveda, F. V. & Cid, L. P., 2018, In: Frontiers in Physiology. 9, APR, 428.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2017

Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K_2P background K⁺ channel TASK-2

Niemeyer, M. I., Cid, L. P., Paulais, M., Teulon, J. & Sepúlveda, F. V., 2017, In: Scientific Reports. 7, 45407.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2016

Gating, Regulation, and structure in K₂P K⁺ Channels: In varietate concordia?

Niemeyer, M. I., Cid, L. P., González, W. & Sepúlveda, F. V., 2016, In: Molecular Pharmacology. 90, 3, p. 309-317 9 p.

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

2015

Analysis of the Latin American west coast rainfall predictability using an enso index

Cid-Serrano, L., Ramírez, S. M., Alfaro, E. J. & Enfield, D. B., 2015, In: Atmosfera. 28, 3, p. 191-203 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Cleft palate, moderate lung developmental retardation and early postnatal lethality in mice deficient in the Kir7.1 inwardly rectifying K⁺ channel

Villanueva, S., Burgos, J., López-Cayuqueo, K. I., Lai, K. M. V., Valenzuela, D. M., Cid, L. P. & Sepúlveda, F. V., 2015, In: PLoS ONE. 10, 9, e0139284.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Molecular aspects of structure, gating, and physiology of pH-sensitive background K_2P and Kir K⁺-transport channels

Sepúlveda, F. V., Cid, L. P., Teulon, J. & Niemeyer, M. I., 2015, In: Physiological Reviews. 95, 1, p. 179-217 39 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

TASK-2 K_2P K⁺ channel: Thoughts about gating and its fitness to physiological function

López-Cayuqueo, K. I., Peña-Münzenmayer, G., Niemeyer, M. I., Sepúlveda, F. V. & Cid, L. P., 2015, In: Pflugers Archiv European Journal of Physiology. 467, 5, p. 1043-1053 11 p.

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

2014

Identification and Functional Expression of a Glutamate- and Avermectin-Gated Chloride Channel from Caligus rogercresseyi, a Southern Hemisphere Sea Louse Affecting Farmed Fish

Cornejo, I., Andrini, O., Niemeyer, M. I., Marabolí, V., González-Nilo, F. D., Teulon, J., Sepúlveda, F. V. & Cid, L. P., 2014, In: PLoS Pathogens. 10, 9

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Zebrafish and mouse TASK-2 K⁺ channels are inhibited by increased CO₂ and intracellular acidification

Peña-Münzenmayer, G., Niemeyer, M. I., Sepúlveda, F. V. & Cid, L. P., 2014, In: Pflugers Archiv European Journal of Physiology. 466, 7, p. 1317-1327 11 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

2013

An extracellular ion pathway plays a central role in the cooperative gating of a K2P K+ channel by extracellular pH

Gonzá lez, W., Zúniga, L., Cid, L. P., Arévalo, B., Niemeyer, M. I. & Sepúlveda, F. V., 2013, In: Journal of Biological Chemistry. 288, 8, p. 5984-5991 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

G protein modulation of K_2P potassium channel TASK-2: A role of basic residues in the C terminus domain

Añazco, C., Peña-Münzenmayer, G., Araya, C., Cid, L. P., Sepúlveda, F. V. & Niemeyer, M. I., 2013, In: Pflugers Archiv European Journal of Physiology. 465, 12, p. 1715-1726 12 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Novel CLCNKB mutations causing bartter syndrome affect channel surface expression

Keck, M., Andrini, O., Lahuna, O., Burgos, J., Cid, L. P., Sepúlveda, F. V., L'Hoste, S., Blanchard, A., Vargas-Poussou, R., Lourdel, S. & Teulon, J., 2013, In: Human Mutation. 34, 9, p. 1269-1278 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

TASK-2: A K2P K+ channel with complex regulation and diverse physiological functions

Cid, L. P., Roa-Rojas, H. A., Niemeyer, M. I., González, W., Araki, M., Araki, K. & Sepúlveda, F. V., 2013, In: Frontiers in Physiology. 4 JUL, Article 198.

Research output: Contribution to journal › Review article › peer-review

Open Access

46 Scopus citations

2011

B lymphocytes taken to task: A role for a background conductance K_2P K⁺ channel in B cells. Focus on "Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells"

Flores, C. A., Cid, L. P., Niemeyer, M. I. & Sepúlveda, F. V., 2011, In: American Journal of Physiology - Cell Physiology. 300, 5, p. C976-C978

Research output: Contribution to journal › Editorial

3 Scopus citations

Extracellular pH in restricted domains as a gating signal for ion channels involved in transepithelial transport

Sandoval, M., Burgos, J., Sepúlveda, F. V. & Cid, L. P., 2011, In: Biological and Pharmaceutical Bulletin. 34, 6, p. 803-809 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Scopus citations

Gating of a pH-sensitive K_2P potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter

Zúñiga, L., Márquez, V., González-Nilo, F. D., Chipot, C., Cid, L. P., Sepúlveda, F. V. & Niemeyer, M. I., 2011, In: PLoS ONE. 6, 1, e16141.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K ⁺ channels

Alzamora, R., O'Mahony, F., Bustos, V., Rapetti-Mauss, R., Urbach, V., Cid, L. P., Sepúlveda, F. V. & Harvey, B. J., 2011, In: Journal of Physiology. 589, 21, p. 5091-5107 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

2010

A tale from the Crypt: Splice variants of BK channels in colonic potassium secretion

Flores, C. A., Cid, L. P. & Sepúlveda, F. V., 2010, In: Journal of Physiology. 588, 11, p. 1807-1808 2 p.

Research output: Contribution to journal › Comment/debate

Open Access

No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy

Niemeyer, M. I., Cid, L. P., Seplveda, F. V., Blanz, J., Auberson, M. & Jentsch, T. J., 2010, In: Nature Genetics. 42, 1, p. 3 1 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

41 Scopus citations

Secular and multidecadal warmings in the North Atlantic and their relationships with major hurricane activity

Enfield, D. B. & Cid-Serrano, L., 2010, In: International Journal of Climatology. 30, 2, p. 174-184 11 p.

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Separate gating mechanisms mediate the regulation of K_2P potassium channel TASK-2 by intra- and extracellular pH

Niemeyer, M. I., Cid, L. P., Pen̈a-Münzenmayer, G. & Sepúlveda, F. V., 2010, In: Journal of Biological Chemistry. 285, 22, p. 16467-16475 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Strain-dependent differences in electrogenic secretion of electrolytes across mouse colon epithelium

Flores, C. A., Cid, L. P. & Sepúlveda, F. V., 2010, In: Experimental Physiology. 95, 6, p. 686-698 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2009

Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: Role of a tyrosine endocytosis motif in surface retrieval

Cornejo, I., Niemeyer, M. I., Zúñiga, L., Yusef, Y. R., Sepúlveda, F. V. & Cid, L. P., 2009, In: Journal of Cellular Physiology. 221, 3, p. 650-657 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

TMEM16 proteins: The long awaited calcium-activated chloride channels?

Flores, C. A., Cid, L. P., Sepúlveda, F. V. & Niemeyer, M. I., 2009, In: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]. 42, 11, p. 993-1001 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

33 Scopus citations

Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons

Niemeyer, M. I., Cid, L. P., Yusef, Y. R., Briones, R. & Sepúlveda, F. V., 2009, In: Journal of Physiology. 587, 7, p. 1387-1400 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

2008

A genetically encoded ratiometric sensor to measure extracellular pH in microdomains bounded by basolateral membranes of epithelial cells

Urra, J., Sandoval, M., Cornejo, I., Barros, L. F., Sepúlveda, F. V. & Cid, L. P., 2008, In: Pflugers Archiv European Journal of Physiology. 457, 1, p. 233-242 10 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

2007

Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K⁺ channel

Niemeyer, M. I., González-Nilo, F. D., Zúñiga, L., Gonzalez, W., Cid, L. P. & Sepulveda, F. V., 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 2, p. 666-671 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

Relación entre diabetes gestacional y síndrome metabólico

Translated title of the contribution: Relationship between gestational diabetes and metabolic syndromeFerrada, C., Molina S, M., Cid, L., Riedel, G., Ferrada, C. & Arévalo, R., 2007, In: Revista Medica de Chile. 135, 12, p. 1539-1545 7 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2006

ClC-2 channels get new partners. Focus on "Association between Hsp90 and the ClC-2 chloride channel upregulates channel function"

Cid, L. P., Niemeyer, M. I. & Sepúlveda, F. V., 2006, In: American Journal of Physiology - Cell Physiology. 290, 1, p. C42-C44

Research output: Contribution to journal › Editorial

2 Scopus citations

Gating of two-pore domain K⁺ channels by extracellular pH

Niemeyer, M. I., González-Nilo, F. D., Zúñiga, L., González, W., Cid, L. P. & Sepúlveda, F. V., 2006, In: Biochemical Society Transactions. 34, 5, p. 899-902 4 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A. L., Roeper, J., Al-Din, A., Hillmer, A. M., Karsak, M., Liss, B., Woods, C. G., Behrens, M. I. & Kubisch, C., 2006, In: Nature Genetics. 38, 10, p. 1184-1191 8 p.

Research output: Contribution to journal › Article › peer-review

1017 Scopus citations

Projecting the risk of future climate shifts

Enfield, D. B. & Cid-Serrano, L., 2006, In: International Journal of Climatology. 26, 7, p. 885-895 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain

Yusef, Y. R., Zúñiga, L., Catalán, M., Niemeyer, M. I., Cid, L. P. & Sepúlveda, F. V., 2006, In: Journal of Physiology. 572, 1, p. 173-181 9 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Two splice variants derived from a Drosophila melanogaster candidate ClC gene generate ClC-2-type Cl^- channels

Flores, C. A., Niemeyer, M. I., Sepúlveda, F. V. & Cid, L. P., 2006, In: Molecular Membrane Biology. 23, 2, p. 149-156 8 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2005

Basolateral localization of native CIC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif

Peña-Münzenmayer, G., Catálan, M., Cornejo, I., Figueroa, C. D., Melvin, J. E., Niemeyer, M. I., Cid, L. P. & Sepúlveda, F. V., 2005, In: Journal of Cell Science. 118, 18, p. 4243-4252 10 p.

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies

Niemeyer, M. I., Yusef, Y. R., Cornejo, I., Flores, C. A., Sepúlveda, F. V. & Cid, L. P., 2005, In: Physiological Genomics. 19, p. 74-83 10 p.

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Putative ClC-2 chloride channel mediates inward rectification in Drosophila retinal photoreceptors

Ugarte, G., Delgado, R., O'Day, P. M., Farjah, F., Cid, L. P., Vergara, C. & Bacigalupo, J., 2005, In: Journal of Membrane Biology. 207, 3, p. 151-160 10 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2004

Basolateral ClC-2 Chloride Channels in Surface Colon Epithelium: Regulation by a Direct Effect of Intracellular Chloride

Catalán, M., Niemeyer, M. I., Cid, L. P. & Sepúlveda, F. V., 2004, In: Gastroenterology. 126, 4, p. 1104-1114 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

70 Scopus citations

The voltage-dependent ClC-2 chloride channel has a dual gating mechanism

Zúñiga, L., Niemeyer, M. I., Varela, D., Catalán, M., Cid, L. P. & Sepúlveda, F. V., 2004, In: Journal of Physiology. 555, 3, p. 671-682 12 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

2003

A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the ClC-2 chloride channel

Niemeyer, M. I., Cid, L. P., Zúñiga, L., Catalán, M. & Sepúlveda, F. V., 2003, In: Journal of Physiology. 553, 3, p. 873-879 7 p.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K⁺ channel without having an essential effect upon activity

Niemeyer, M. I., Cid, L. P., Valenzuela, X., Paeile, V. & Sepúlveda, F. V., 2003, In: Molecular Membrane Biology. 20, 2, p. 185-191 7 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Luis Pablo Cid Soto, MSc

Research output

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