Gonzalo Antonio Mardones Cofre

2024

AP-1γ2 is an adaptor protein 1 variant required for endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR) and ATP7B copper transporter

Tavares, L. A., Rodrigues, R. L., Santos da Costa, C., Nascimento, J. A., Vargas de Carvalho, J., Nogueira de Carvalho, A., Mardones, G. A. & daSilva, L. L. P., 2024, In: Journal of Biological Chemistry. 300, 3, 105700.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

GOLPH3 Participates in Mitochondrial Fission and Is Necessary to Sustain Bioenergetic Function in MDA-MB-231 Breast Cancer Cells

Polanco, C. M., Cavieres, V. A., Galarza, A. J., Jara, C., Torres, A. K., Cancino, J., Varas-Godoy, M., Burgos, P. V., Tapia-Rojas, C. & Mardones, G. A., 2024, In: Cells. 13, 4, 316.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

The Reelin receptor ApoER2 is a cargo for the adaptor protein complex AP-4: Implications for Hereditary Spastic Paraplegia

Caracci, M. O., Pizarro, H., Alarcón-Godoy, C., Fuentealba, L. M., Farfán, P., De Pace, R., Santibañez, N., Cavieres, V. A., Pástor, T. P., Bonifacino, J. S., Mardones, G. A. & Marzolo, M. P., 2024, In: Progress in Neurobiology. 234, 102575.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2023

Antiviral Activity of an Endogenous Parvoviral Element

Bravo, A., Fernández-García, L., Ibarra-Karmy, R., Mardones, G. A., Mercado, L., Bustos, F. J., Gifford, R. J. & Arriagada, G., 2023, In: Viruses. 15, 7, 1420.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Correction to: Golgi Phosphoprotein 3 Regulates the Physical Association of Glycolipid Glycosyltransferases (International Journal of Molecular Sciences, (2022), 23, 18, (10354), 10.3390/ijms231810354)

Ruggiero, F. M., Martínez-Koteski, N., Cavieres, V. A., Mardones, G. A., Fidelio, G. D., Vilcaes, A. A. & Daniotti, J. L., 2023, In: International Journal of Molecular Sciences. 24, 17, 13212.

Research output: Contribution to journal › Comment/debate

Open Access

1 Scopus citations

Discovery of BbX transcription factor in the patagonian blennie: Exploring expression changes following combined bacterial and thermal stress exposure

Martínez, D., Nualart, D., Loncoman, C., Opazo, J. C., Zabala, K., Morera, F. J., Mardones, G. A. & Vargas-Chacoff, L., 2023, In: Developmental and Comparative Immunology. 149, 105056.

Research output: Contribution to journal › Article › peer-review

Open Access

Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection

Luchsinger, C., Lee, K. E., Mardones, G. A., KewalRamani, V. N. & Diaz-Griffero, F., 2023, In: Scientific Reports. 13, 1, 10974.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member

Opazo, J. C., Vandewege, M. W., Hoffmann, F. G., Zavala, K., Meléndez, C., Luchsinger, C., Cavieres, V. A., Vargas-Chacoff, L., Morera, F. J., Burgos, P. V., Tapia-Rojas, C. & Mardones, G. A., 2023, In: Molecular Biology and Evolution. 40, 2, msad014.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

S-Nitrosylation in endothelial cells contributes to tumor cell adhesion and extravasation during breast cancer metastasis

Koning, T., Cordova, F., Aguilar, G., Sarmiento, J., Mardones, G. A., Boric, M., Varas-Godoy, M., Lladser, A., Duran, W. N., Ehrenfeld, P. & Sanchez, F. A., 2023, In: Biological Research. 56, 1, 51.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2022

Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates

Opazo, J. C., Zavala, K., Vargas-Chacoff, L., Morera, F. J. & Mardones, G. A., 2022, In: Scientific Reports. 12, 1, 3823.

Research output: Contribution to journal › Article › peer-review

Open Access

Single-Fluorophore Indicator to Explore Cellular and Sub-cellular Lactate Dynamics

Aburto, C., Galaz, A., Bernier, A., Sandoval, P. Y., Holtheuer-Gallardo, S., Ruminot, I., Soto-Ojeda, I., Hertenstein, H., Schweizer, J. A., Schirmeier, S., Pástor, T. P., Mardones, G. A., Barros, L. F. & San Martín, A., 2022, In: ACS Sensors. 7, 11, p. 3278-3286 9 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2021

Independent duplications of the Golgi phosphoprotein 3 oncogene in birds

Opazo, J. C., Vandewege, M. W., Gutierrez, J., Zavala, K., Vargas-Chacoff, L., Morera, F. J. & Mardones, G. A., 2021, In: Scientific Reports. 11, 1, 12483.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2020

GOLPH3 regulates EGFR in T98G glioblastoma cells by modulating its glycosylation and ubiquitylation

Arriagada, C., Cavieres, V. A., Luchsinger, C., González, A. E., Muñoz, V. C., Cancino, J., Burgos, P. V. & Mardones, G. A., 2020, In: International Journal of Molecular Sciences. 21, 22, p. 1-30 30 p., 8880.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B

Caviere, V. A., Cerda-Troncoso, C., Rivera-Dictter, A., Castr, R. I., Luchsinger, C., Santibañez, N., Burgo, P. V. & Mardone, G. A., 2020, In: Plos One . 15, 8 August, e0237514.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Imaging of the Lactate/Pyruvate Ratio Using a Genetically Encoded Förster Resonance Energy Transfer Indicator

Galaz, A., Cortés-Molina, F., Arce-Molina, R., Romero-Gómez, I., Mardones, G. A., Felipe Barros, L. & San Martín, A., 2020, In: Analytical Chemistry. 92, 15, p. 10643-10650 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Publisher Correction: α-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility (Scientific Reports, (2017), 7, 1, (11765), 10.1038/s41598-017-12292-9)

Arcos, A., de Paola, M., Gianetti, D., Acuña, D., Velásquez, Z. D., Miró, M. P., Toro, G., Hinrichsen, B., Muñoz, R. I., Lin, Y., Mardones, G. A., Ehrenfeld, P., Rivera, F. J., Michaut, M. A. & Batiz, L. F., 2020, In: Scientific Reports. 10, 1, 5691.

Research output: Contribution to journal › Comment/debate

Open Access

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport

Bustamante, H. A., Cereceda, K., González, A. E., Valenzuela, G. E., Cheuquemilla, Y., Hernández, S., Arias-Muñoz, E., Cerda-Troncoso, C., Bandau, S., Soza, A., Kausel, G., Kerr, B., Mardones, G. A., Cancino, J., Hay, R. T., Rojas-Fernandez, A. & Burgos, P. V., 2020, In: Cells. 9, 3, 1694.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2019

Electron Tomography Revels that Milk Lipids Originate from Endoplasmic Reticulum Domains with Novel Structural Features

Ladinsky, M. S., Mardones, G. A., Orlicky, D. J., Howell, K. E. & McManaman, J. L., 2019, In: Journal of Mammary Gland Biology and Neoplasia. 24, 4, p. 293-304 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

13 Scopus citations

Galectin-8 induces endothelial hyperpermeability through the eNOS pathway involving S-nitrosylation-mediated adherens junction disassembly

Zamorano, P., Koning, T., Oyanadel, C., Mardones, G. A., Ehrenfeld, P., Boric, M. P., González, A., Soza, A. & Sánchez, F. A., 2019, In: Carcinogenesis. 40, 2, p. 313-323 11 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover

Tapia, D., Jiménez, T., Zamora, C., Espinoza, J., Rizzo, R., González-Cárdenas, A., Fuentes, D., Hernández, S., Cavieres, V. A., Soza, A., Guzmán, F., Arriagada, G., Yuseff, M. I., Mardones, G. A., Burgos, P. V., Luini, A., González, A. & Cancino, J., 2019, In: Nature Communications. 10, 1, 735.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner

Arriagada, C., Luchsinger, C., González, A. E., Schwenke, T., Arriagada, G., Folch, H., Ehrenfeld, P., Burgos, P. V. & Mardones, G. A., 2019, In: Plos One . 14, 2, e0212321.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2018

Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling

Luchsinger, C., Aguilar, M., Burgos, P. V., Ehrenfeld, P. & Mardones, G. A., 2018, In: Plos One . 13, 4, e0195401.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

HIV/SIV-Nef: Pas de trois Choreographies to Evade Immunity

daSilva, L. L. P. & Mardones, G. A., 2018, In: Trends in Microbiology. 26, 11, p. 889-891 3 p.

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

2017

Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway

González, A. E., Muñoz, V. C., Cavieres, V. A., Bustamante, H. A., Cornejo, V. H., Januário, Y. C., González, I., Hetz, C., Dasilva, L. L., Rojas-Fernández, A., Hay, R. T., Mardones, G. A. & Burgos, P. V., 2017, In: FASEB Journal. 31, 6, p. 2446-2459 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the γ1 and γ2 subunits of the AP-1 complex in protein trafficking

Tavares, L. A., da Silva, E. M. L., da Silva-Januário, M. E., Januário, Y. C., de Cavalho, J. V., Czernisz, É. S., Mardones, G. A. & daSilva, L. L. P., 2017, In: Journal of Cell Science. 130, 2, p. 429-443 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

α-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility

Arcos, A., Paola, M. D., Gianetti, D., Acuña, D., Velásquez, Z. D., Miró, M. P., Toro, G., Hinrichsen, B., Muñoz, R. I., Lin, Y., Mardones, G. A., Ehrenfeld, P., Rivera, F. J., Michaut, M. A. & Batiz, L. F., 2017, In: Scientific Reports. 7, 1, 11765.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2016

Distinct biochemical pools of Golgi phosphoprotein 3 in the human breast cancer cell lines MCF7 and MDA-MB-231

Tenorio, M. J., Ross, B. H., Luchsinger, C., Rivera-Dictter, A., Arriagada, C., Acuña, D., Aguilar, M., Cavieres, V., Burgos, P. V., Ehrenfeld, P. & Mardones, G. A., 2016, In: Plos One . 11, 4, e0154719.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc

Barriga, G. P., Villalón-Letelier, F., Márquez, C. L., Bignon, E. A., Acuña, R., Ross, B. H., Monasterio, O., Mardones, G. A., Vidal, S. E. & Tischler, N. D., 2016, In: PLoS Neglected Tropical Diseases. 10, 7, e0004799.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2015

Protein kinase a activity is necessary for fission and fusion of golgi to endoplasmic reticulum retrograde tubules

Tenorio, M. J., Luchsinger, C. & Mardones, G. A., 2015, In: PLoS ONE. 10, 8, e0135260.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Tetrahydrohyperforin inhibits the proteolytic processing of amyloid precursor protein and enhances its degradation by Atg5-dependent autophagy

Cavieres, V. A., González, A., Muñoz, V. C., Yefi, C. P., Bustamante, H. A., Barraza, R. R., Tapia-Rojas, C., Otth, C., Barrera, M. J., González, C., Mardones, G. A., Inestrosa, N. C. & Burgos, P. V., 2015, In: Plos One . 10, 8, e0136313.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2014

Co-assembly of Viral Envelope Glycoproteins Regulates Their Polarized Sorting in Neurons

Mattera, R., Farías, G. G., Mardones, G. A. & Bonifacino, J. S., 2014, In: PLoS Pathogens. 10, 5, e1004107.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Structural and functional characterization of cargo-binding sites on the μ4-subunit of adaptor protein complex 4

Ross, B. H., Lin, Y., Corales, E. A., Burgos, P. V. & Mardones, G. A., 2014, In: Plos One . 9, 2, e88147.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

2013

Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex

Mardones, G. A., Burgos, P. V., Lin, Y., Kloer, D. P., Magadán, J. G., Hurley, J. H. & Bonifacino, J. S., 2013, In: Journal of Biological Chemistry. 288, 13, p. 9563-9571 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells

Bustamante, H. A., Rivera-Dictter, A., Cavieres, V. A., Muñoz, V. C., González, A., Lin, Y., Mardones, G. A. & Burgos, P. V., 2013, In: Plos One . 8, 12, e83096.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2010

AGAP2 regulates retrograde transport between early endosomes and the TGN

Shiba, Y., Römer, W., Mardones, G. A., Burgos, P. V., Lamaze, C. & Johannes, L., 2010, In: Journal of Cell Science. 123, 14, p. 2381-2390 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Ang2/fat-free is a conserved subunit of the golgi-associated retrograde protein complex

Pérez-Victoria, F. J., Schindler, C., Magadán, J. G., Mardones, G. A., Delevoye, C., Romao, M., Raposo, G. & Bonifacino, J. S., 2010, In: Molecular Biology of the Cell. 21, 19, p. 3386-3395 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex

Burgos, P. V., Mardones, G. A., Rojas, A. L., daSilva, L. L. P., Prabhu, Y., Hurley, J. H. & Bonifacino, J. S., 2010, In: Developmental Cell. 18, 3, p. 425-436 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

210 Scopus citations

Termination of autophagy and reformation of lysosomes regulated by mTOR

Yu, L., McPhee, C. K., Zheng, L., Mardones, G. A., Rong, Y., Peng, J., Mi, N., Zhao, Y., Liu, Z., Wan, F., Hailey, D. W., Oorschot, V., Klumperman, J., Baehrecke, E. H. & Lenardo, M. J., 2010, In: Nature. 465, 7300, p. 942-946 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1279 Scopus citations

2009

Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes

Popoff, V., Mardones, G. A., Bai, S. K., Chambon, V., Tenza, D., Burgos, P. V., Shi, A., Benaroch, P., Urbé, S., Lamaze, C., Grant, B. D., Raposo, G. & Johannes, L., 2009, In: Traffic. 10, 12, p. 1868-1880 13 p.

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Coatomer-dependent protein delivery to lipid droplets

Soni, K. G., Mardones, G. A., Sougrat, R., Smirnova, E., Jackson, C. L. & Bonifacino, J. S., 2009, In: Journal of Cell Science. 122, 11, p. 1834-1841 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

214 Scopus citations

2008

Protein transport from the trans-Golgi network to endosomes

Mardones, G. A., Polishchuk, R. S. & Bonifacino, J. S., 2008, The Golgi Apparatus: State of the Art 110 Years after Camillo Golgi's Discovery. Springer-Verlag Wien, p. 388-401 14 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Requirement of the human GARP complex for mannose 6-phosphate-receptor- dependent sorting of cathepsin D to lysosomes

Pérez-Victoria, F. J., Mardones, G. A. & Bonifacino, J. S., 2008, In: Molecular Biology of the Cell. 19, 6, p. 2350-2362 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

130 Scopus citations

2007

The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting

Mardones, G. A., Burgos, P. V., Brooks, D. A., Parkinson-Lawrence, E., Mattera, R. & Bonifacino, J. S., 2007, In: Molecular Biology of the Cell. 18, 9, p. 3486-3501 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

2006

Cis-Golgi matrix proteins move directly to endoplasmic reticulum exit sites by association with tubules

Mardones, G. A., Snyder, C. M. & Howell, K. E., 2006, In: Molecular Biology of the Cell. 17, 1, p. 525-538 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

GMx33 associates with the trans-Golgi matrix in a dynamic manner and sorts within tubules exiting the Golgi

Snyder, C. M., Mardones, G. A., Ladinsky, M. S. & Howell, K. E., 2006, In: Molecular Biology of the Cell. 17, 1, p. 511-524 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

2004

Organellar proteomics reveals Golgi arginine dimethylation

Wu, C. C., MacCoss, M. J., Mardones, G., Finnigan, C., Mogelsvang, S., Yates, J. R. & Howell, K. E., 2004, In: Molecular Biology of the Cell. 15, 6, p. 2907-2919 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

123 Scopus citations

2003

Selective plasma membrane permeabilization by freeze-thawing and immunofluorescence epitope access to determine the topology of intracellular membrane proteins

Mardones, G. & González, A., 2003, In: Journal of Immunological Methods. 275, 1-2, p. 169-177 9 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2000

Chromogenic plate assay distinguishing bacteriolytic from bacteriostatic activity of an antibiotic agent

Mardones, G. & Venegas, A., 2000, In: Journal of Microbiological Methods. 40, 3, p. 199-206 8 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Gonzalo Antonio Mardones Cofre, PhD

Research output

Search results