Gonzalo Antonio Mardones Cofre

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Personal profile

Dr. Gonzalo Mardones is a biochemist at the Universidad Austral de Chile. He has a doctorate in Biological Sciences with a mention in Cellular and Molecular Biology from the Pontifical Catholic University of Chile. He completed two postdoctoral internships, one at the Department of Cell and Developmental Biology at the University of Colorado in the city of Denver, USA, and a second at the National Institutes of Health (NIH) in the city of Bethesda, state of Maryland. , USA. Before joining the USS he was an academic at the Faculty of Medicine of the Universidad Austral de Chile, in Valdivia.

Teaching

At the USS he has been a collaborator and currently a member of the faculty of the doctoral program in Cellular Biology and Biomedicine, teaching in Experimental methods in structural biology for biomedicine, Biomolecular condensates and their impact on human health, and Structural bases of cellular pathology.

Research interests

His research group studies the structural and evolutionary bases of the molecular mechanisms that allow compartmentalization within cells, with emphasis on those that occur in the Golgi apparatus, and their relationship with pathological processes such as cancer and neurodegenerative diseases. It uses a multidisciplinary experimental strategy combining methodologies such as X-ray crystallography and fluorescence microscopy in living cells.

External positions

Universidad Austral de Chile

2010 → 2023

National Institutes of Health, Bethesda, Maryland, EEUU

2008 → 2010

National Institutes of Health, Bethesda, Maryland, EEUU

2005 → 2008

Universidad de Colorado, Denver, Colorado, EEUU

2003 → 2005

Pontificia Universidad Católica de Chile

1998 → 1999

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

SDG 3 Good Health and Well-being

Fingerprint

Dive into the research topics where Gonzalo Antonio Mardones Cofre is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

1 Similar Profiles

2 Finished
2 Active

FONDECYT R-1250688: Unraveling the functional evolution of galectin-8 throughout its evolutionary history
Opazo Carvallo, J. C. A. (Investigador(a) Responsable), Mardones Cofre, G. A. (CoI) & Soza Gajardo, A. M. (CoI)
01/04/25 → 31/03/29
Project: PROYECTO DE INVESTIGACIÓN
FONDECYT R-1251655: Regulation of oncoprotein GOLPH3 degradation by phosphorylation: implications for the progression of triple-negative breast cancer
Mardones Cofre, G. A. (Investigador(a) Responsable), Burgos Hitschfeld, P. V. (CoI) & Ehrenfeld Slater, I. (CoI)
01/04/25 → 31/03/29
Project: PROYECTO DE INVESTIGACIÓN
FONDECYT R-1211481: Partitioning of the oncoprotein GOLPH3 in biomolecular condensates by liquid-liquid phase separation: a mechanism for the phenotypic plasticity of breast cancer cells
Mardones Cofre, G. A. (Investigador(a) Responsable), Burgos Hitschfeld, P. V. (CoI), Ehrenfeld Slater, I. (CoI) & Araya, C. (CoI)
01/04/21 → 31/03/25
Project: PROYECTO DE INVESTIGACIÓN
FONDECYT R-1211261: The interplay between phosphorylation and ubiquitylation controls stabilization of HERPUD1 under ER stress: possible implications on TNBC aggressiveness
Burgos Hitschfeld, P. V. (Investigador(a) Responsable), Varas Godoy, M. A. (CoI), Mardones Cofre, G. A. (CoI) & Barrera Alvarado, M. J. (CoI)
01/04/21 → 31/03/25
Project: PROYECTO DE INVESTIGACIÓN

29 Article
3 Comment/debate
1 Chapter
1 Short survey

A Simplified Strategy for Nanobody Production and Use Based on Functional GST-Nanobody Fusion Proteins
Burgos, A. A., Rivera-Dictter, A., Mendoza-Soto, P., Pástor, T. P., Munizaga, J., Valenzuela-Nieto, G. & Mardones, G. A., 2026, In: Biomolecules. 16, 2, 306.
Research output: Contribution to journal › Article › peer-review

Open Access
Evolutionary and Functional Analysis of Monoamine Oxidase F: A Novel Member of the Monoamine Oxidase Gene Family
Merello Oyarzún, G., Olivares-Costa, M., Basile, L., Pástor, T. P., Mendoza-Soto, P., Padilla-Santiago, L., Mardones, G. A., Binda, C. & Opazo, J. C., 2025, In: Genome Biology and Evolution. 17, 2, evae280.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations
HERPUD1 mediates palmitic acid-induced UPR sustaining TNBC aggressiveness and is destabilized by CK2 pharmacological inhibition
Cavieres, V. A., Cortés, O., Arias-Muñoz, E., Álvarez-Indo, J., Aguilera-Olguín, M., Hernández, R., Silva-Pavez, E., Tapia, J. C., Cancino, J., Lagos, C. F., Pástor, T. P., Galarza, A. J., Mardones, G. A., Varas-Godoy, M., Villarreal-Cruz, N., Villarroel-Espindola, F., Saffie, I., González, A., Barrera, M. J. & Ehrenfeld, P. & 4 others, Burgos, P. V., Hernández Torres, L., Catalán Aguilera, J. A. & Cruzat Arias, F., 2025, In: Cell Death and Disease. 16, 1, 793.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
AP-1γ2 is an adaptor protein 1 variant required for endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR) and ATP7B copper transporter
Tavares, L. A., Rodrigues, R. L., Santos da Costa, C., Nascimento, J. A., Vargas de Carvalho, J., Nogueira de Carvalho, A., Mardones, G. A. & daSilva, L. L. P., 2024, In: Journal of Biological Chemistry. 300, 3, 105700.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Scopus citations
Corrigendum to “The Reelin receptor ApoER2 is a cargo for the adaptor protein complex AP-4: Implications for hereditary spastic paraplegia” [Progr. Neurobiol. 234(2024)102575](S030100822400011X)(10.1016/j.pneurobio.2024.102575)
Caracci, M. O., Pizarro, H., Alarcón-Godoy, C., Fuentealba, L. M., Farfán, P., De Pace, R., Santibañez, N., Cavieres, V. A., Pástor, T. P., Bonifacino, J. S., Mardones, G. A. & Marzolo, M. P., 2024, In: Progress in Neurobiology. 241, 102662.
Research output: Contribution to journal › Comment/debate

Open Access

Gonzalo Antonio Mardones Cofre, PhD

Personal profile

Personal profile

Teaching

Research interests

External positions

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

FONDECYT R-1250688: Unraveling the functional evolution of galectin-8 throughout its evolutionary history

FONDECYT R-1251655: Regulation of oncoprotein GOLPH3 degradation by phosphorylation: implications for the progression of triple-negative breast cancer

FONDECYT R-1211481: Partitioning of the oncoprotein GOLPH3 in biomolecular condensates by liquid-liquid phase separation: a mechanism for the phenotypic plasticity of breast cancer cells

FONDECYT R-1211261: The interplay between phosphorylation and ubiquitylation controls stabilization of HERPUD1 under ER stress: possible implications on TNBC aggressiveness

A Simplified Strategy for Nanobody Production and Use Based on Functional GST-Nanobody Fusion Proteins

Evolutionary and Functional Analysis of Monoamine Oxidase F: A Novel Member of the Monoamine Oxidase Gene Family

HERPUD1 mediates palmitic acid-induced UPR sustaining TNBC aggressiveness and is destabilized by CK2 pharmacological inhibition

AP-1γ2 is an adaptor protein 1 variant required for endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR) and ATP7B copper transporter

Corrigendum to “The Reelin receptor ApoER2 is a cargo for the adaptor protein complex AP-4: Implications for hereditary spastic paraplegia” [Progr. Neurobiol. 234(2024)102575](S030100822400011X)(10.1016/j.pneurobio.2024.102575)

Gonzalo Antonio Mardones Cofre, PhD

Personal profile

Personal profile

Teaching

Research interests

External positions

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Projects

Research output