Projects per year
Personal profile
Personal profile
Dr. Gonzalo Mardones is a biochemist at the Universidad Austral de Chile. He has a doctorate in Biological Sciences with a mention in Cellular and Molecular Biology from the Pontifical Catholic University of Chile. He completed two postdoctoral internships, one at the Department of Cell and Developmental Biology at the University of Colorado in the city of Denver, USA, and a second at the National Institutes of Health (NIH) in the city of Bethesda, state of Maryland. , USA. Before joining the USS he was an academic at the Faculty of Medicine of the Universidad Austral de Chile, in Valdivia.
Teaching
At the USS he has been a collaborator and currently a member of the faculty of the doctoral program in Cellular Biology and Biomedicine, teaching in Experimental methods in structural biology for biomedicine, Biomolecular condensates and their impact on human health, and Structural bases of cellular pathology.
Research interests
His research group studies the structural and evolutionary bases of the molecular mechanisms that allow compartmentalization within cells, with emphasis on those that occur in the Golgi apparatus, and their relationship with pathological processes such as cancer and neurodegenerative diseases. It uses a multidisciplinary experimental strategy combining methodologies such as X-ray crystallography and fluorescence microscopy in living cells.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Universidad Austral de Chile
2010 → 2023
National Institutes of Health, Bethesda, Maryland, EEUU
2008 → 2010
National Institutes of Health, Bethesda, Maryland, EEUU
2005 → 2008
Universidad de Colorado, Denver, Colorado, EEUU
2003 → 2005
Pontificia Universidad Católica de Chile
1998 → 1999
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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FONDECYT R-1251655: Regulation of oncoprotein GOLPH3 degradation by phosphorylation: implications for the progression of triple-negative breast cancer
Mardones Cofre, G. A. (Investigador(a) Responsable), Burgos Hitschfeld, P. V. (CoI) & Ehrenfeld Slater, I. (CoI)
01/04/25 → 31/03/29
Project: PROYECTO DE INVESTIGACIÓN
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FONDECYT R-1211261: The interplay between phosphorylation and ubiquitylation controls stabilization of HERPUD1 under ER stress: possible implications on TNBC aggressiveness
Burgos Hitschfeld, P. V. (Investigador(a) Responsable), Varas Godoy, M. A. (CoI), Mardones Cofre, G. A. (CoI) & Barrera Alvarado, M. J. (CoI)
01/04/21 → 31/03/25
Project: PROYECTO DE INVESTIGACIÓN
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FONDECYT R-1211481: Partitioning of the oncoprotein GOLPH3 in biomolecular condensates by liquid-liquid phase separation: a mechanism for the phenotypic plasticity of breast cancer cells
Mardones Cofre, G. A. (Investigador(a) Responsable), Burgos Hitschfeld, P. V. (CoI), Ehrenfeld Slater, I. (CoI) & Araya, C. (CoI)
01/04/21 → 31/03/25
Project: PROYECTO DE INVESTIGACIÓN
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Evolutionary and Functional Analysis of Monoamine Oxidase F: A Novel Member of the Monoamine Oxidase Gene Family
Merello Oyarzún, G., Olivares-Costa, M., Basile, L., Pástor, T. P., Mendoza-Soto, P., Padilla-Santiago, L., Mardones, G. A., Binda, C. & Opazo, J. C., 2025, In: Genome Biology and Evolution. 17, 2, evae280.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
AP-1γ2 is an adaptor protein 1 variant required for endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR) and ATP7B copper transporter
Tavares, L. A., Rodrigues, R. L., Santos da Costa, C., Nascimento, J. A., Vargas de Carvalho, J., Nogueira de Carvalho, A., Mardones, G. A. & daSilva, L. L. P., 2024, In: Journal of Biological Chemistry. 300, 3, 105700.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Evolution of ion channels in cetaceans: a natural experiment in the tree of life
Uribe, C., Nery, M. F., Zavala, K., Mardones, G. A., Riadi, G. & Opazo, J. C., 2024, In: Scientific Reports. 14, 1, 17024.Research output: Contribution to journal › Article › peer-review
Open Access -
GOLPH3 Participates in Mitochondrial Fission and Is Necessary to Sustain Bioenergetic Function in MDA-MB-231 Breast Cancer Cells
Polanco, C. M., Cavieres, V. A., Galarza, A. J., Jara, C., Torres, A. K., Cancino, J., Varas-Godoy, M., Burgos, P. V., Tapia-Rojas, C. & Mardones, G. A., 2024, In: Cells. 13, 4, 316.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Pharmacological Blockade of the Adenosine A2B Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of Podocytes
Mendoza-Soto, P., Jara, C., Torres-Arévalo, Á., Oyarzún, C., Mardones, G. A., Quezada-Monrás, C. & San Martín, R., 2024, In: Cells. 13, 10, 846.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations