Research output per year
Research output per year
Personal profile
Personal profile
Francisco Sáez obtained his doctorate degree in Biological Sciences at Universidad de
Concepción, in Chile. Later, he did a postdoctoral training at the Université catholique de Louvain in Belgium, with a Becas Chile scholarship. Currently, he is an Assistant Professor at the Faculty of Medicine and Science in the Universidad San Sebastián (USS). He participates as a professor of human physiology and is part of the teaching body of Medical Technology.
Teaching
Francisco currently teaches in the Human Physiology course.
Research interests
Dr. Sáez has a great interest in neurodegenerative diseases, in particular Alzheimer’s
disease, and how the metabolism of saturated fatty acids can interact with the Amyloid Precursor Protein, and promote the development of the pathology, and the effect of saturated fatty acids on normal neuronal function.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Neuroprotective Properties of Eudesmin on a Cellular Model of Amyloid-β Peptide Toxicity
Castillo, C., Bravo-Arrepol, G., Wendt, A., Saez-Orellana, F., Millar, C., Burgos, C. F., Gavilán, J., Pacheco, C., Ahumada-Rudolph, R., Napiórkowska, M., Pérez, C., Becerra, J., Fuentealba, J. & Cabrera-Pardo, J. R., 2023, In: Journal of Alzheimer's Disease. 94, p. S97-S108Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
New Benzodihydrofuran Derivatives Alter the Amyloid β Peptide Aggregation: Strategies To Develop New Anti-Alzheimer Drugs
Sánchez, Y., Castillo, C., Fuentealba, J., Sáez-Orellana, F., Burgos, C. F., López, J. J., F. de la Torre, A. & Jiménez, C. A., 2023, In: ACS Chemical Neuroscience. 14, 15, p. 2590-2602 13 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Microglial Activation Modulated by P2X4R in Ischemia and Repercussions in Alzheimer’s Disease
Castillo, C., Saez-Orellana, F., Godoy, P. A. & Fuentealba, J., 2022, In: Frontiers in Physiology. 13, 814999.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations -
Regulation of PPAR α by APP in Alzheimer disease affects the pharmacological modulation of synaptic activity
Sáez-Orellana, F., Leroy, T., Ribeiro, F., Kreis, A., Leroy, K., Lalloyer, F., Baugé, E., Staels, B., Duyckaerts, C., Brion, J. P., Gailly, P., Octave, J. N. & Pierrot, N., 2021, In: JCI Insight. 6, 16, e150099.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Alzheimer's Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α
Sáez-Orellana, F., Octave, J. N. & Pierrot, N., 2020, In: Cells. 9, 5, 1199.Research output: Contribution to journal › Review article › peer-review
Open Access36 Scopus citations