Projects per year
Personal profile
Personal profile
Dr. Eduardo Silva Pavez holds a bachelor’s degree in Biochemistry and is a Biochemist from the Pontificia Universidad Católica de Valparaíso. Later, driven by an interest in scientific research, he pursued a doctoral degree in Pharmacology at the University de Chile. In 2019, he joined the Laboratory of Cellular Metabolism and Bioenergetics at Universidad Mayor as a Postdoctoral Researcher. He is a regular academic and researcher at the Facultad de Odontología y Ciencias de la Rehabilitación at the Universidad San Sebastián.
Teaching
Dr. Eduardo Silva Pavez serves as a teacher in basic sciences, mainly teaching Biochemistry, Cellular, and Molecular Biology, at the Facultad de Odontología y Ciencias de la Rehabilitación at the Universidad San Sebastián.
Research interests
His scientific interests are focused on studying the cellular and molecular biology of cancer, emphasizing processes related to tumor recurrence and the role of cellular metabolism, also in the search for new molecular targets that allow us to selectively affect the viability and proliferation of cancer cells, through pharmacological and molecular approaches, and more recently, bioenergetic and metabolic ones. On the other hand, the majority of his scientific publications focus on understanding the functioning of the signaling transduction pathways that are hyperactivated in different types of tumors, such as the Wnt/β-catenin, Ca2+/IP3Rs, and PI3K/Akt/mTOR pathways, as well as understanding the role of Ser/Thr-kinases (e.g. CK2, Akt, mTOR, and AMPK) in tumor viability, autophagy, proliferation, and metabolism.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Universidad Mayor, Santiago, Chile
2019 → 2021
Cargo USS
- Investigador (a)
Jerarquía Académica
- Profesor Asistente
Fingerprint
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Collaborations and top research areas from the last five years
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Projects
- 1 Active
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FONDECYT I-11251042: SLC38A9/mTORC1/YY1: an unveiled signaling pathway that promotes breast cancer aggressiveness
Silva Pavez, E. E. (Investigador(a) Responsable)
01/04/25 → 31/03/28
Project: PROYECTO DE INVESTIGACIÓN
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Calcium (Ca2+) fluxes at mitochondria-ER contact sites (MERCS) are a new target of senolysis in therapy-induced senescence (TIS)
Puebla-Huerta, A., Huerta, H., Quezada-Gutierez, C., Morgado-Cáceres, P., Casanova-Canelo, C., Niño, S. A., Linsambarth, S., Rivera, O. D., López-Domínguez, J. A., RODRIGUEZ-LOPEZ, S., González-Reyes, J. A., Bustos, G., Silva-Pavez, E., Lovy, A., Quiroz, G., González-Seguel, C., Salas-Huenuleo, E., Kogan, M. J., Molgó, J. & Zakarian, A. & 5 others, , 2025, In: npj Aging. 11, 1, 11.Research output: Contribution to journal › Article › peer-review
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Mitochondria-derived reactive oxygen species induce over-differentiation of neural stem/progenitor cells after non-cytotoxic cisplatin exposure
Bustamante-Barrientos, F. A., Lara-Barba, E., Herrera-Luna, Y., García-Guerrero, C., Silva-Pavez, E., Morales-Reyes, J., Araya, M. J., Yanten-Fuentes, L., Luque-Campos, N., Altamirano, C., Vega-Letter, A. M. & Luz-Crawford, P., 2025, In: Frontiers in Cell and Developmental Biology. 13, 1555153.Research output: Contribution to journal › Article › peer-review
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The IP3R inhibitor desmethylxestospongin B reduces tumor cell migration, invasion and metastasis by impairing lysosome acidification and β1-integrin recycling
Bustos, G., Ahumada-Castro, U., Silva-Pavez, E., Huerta, H., Puebla, A., Quezada, C., Morgado-Cáceres, P., Casanova-Canelo, C., Smith-Cortinez, N., Podunavac, M., Oyarce, C., Lladser, A., Farias, P., Lovy, A., Molgó, J., Torres, V. A., Zakarian, A. & Cárdenas, J. C., 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 1, 167557.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Calcium (Ca2+) fluxes at Mitochondria-ER Contact Sites (MERCS) are a new target of senolysis in Therapy-Induced Senescence (TIS).
Puebla-Huerta, A., Huerta, H., Quezada-Gutierez, C., Morgado-Cáceres, P., Casanova-Canelo, C., Linsambarth, S., Díaz-Rivera, O., López-Domínguez, J. A., Rodríguez-López, S., Bustos, G., Silva-Pavez, E., Lovy, A., Quiroz, G., González-Seguel, C., Salas-Huenuleo, E., Kogan, M. J., Molgó, J., Zakarian, A., Villalba, J. M. & Gonzalez-Billault, C. & 2 others, , 2024.Research output: Working paper › Preprint
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Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells
Almarza, C., Villalobos-Nova, K., Toro, M. A., González, M., Niechi, I., Brown‑Brown, D. A., López-Muñoz, R. A., Silva-Pavez, E., Gaete-Ramírez, B., Varas-Godoy, M., Burzio, V. A., Jara, L., Aguayo, F. & Tapia, J. C., 2024, In: Biological Research. 57, 1, 74.Research output: Contribution to journal › Article › peer-review
Open Access